Chronic Pancreatitis, Exocrine Pancreatic Insufficiency
Conditions
Keywords
pancreatic function test, Pancreatic fluid composition
Brief summary
The purpose of this study is to collect pancreas fluid from the duodenum using the endoscopic pancreas function collection method in healthy participants after pancreatic stimulation with human secretin.
Interventions
During endoscopic ultrasound (EUS), a dose of intravenous secretin (0.2 µg/kg) will be administered over the course of 1 minute to stimulate pancreatic ductal cells to secrete pancreas fluid. Duodenal fluid will be aspirated through the echoendoscope in 5 minute increments (5, 10, 15, and 20 minutes) after the secretin has been administered
Sponsors
Mayo Clinic
ChiRhoClin, Inc.
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
* Males or non-pregnant females * Age 18-80. * Participants must be in good health based on medical history (ASA Class 3 or below) * Participants must be willing and able to provide informed consent * Receiving an endoscopic ultrasound for a non-pancreatic indication
Exclusion criteria
* History of any form of pancreatitis and/or other pancreatic diseases (e.g. pancreatic cysts, pancreatic masses). * History of inflammatory bowel disease * History of vagotomy. * History of surgically altered upper gastrointestinal anatomy (e.g. gastric bypass, Billroth I/II) * History of liver disease * Pregnant women or nursing mothers * Regular use of anticholinergics * \> 2 drinks of alcohol daily * Smokers (cigarette)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Pancreatic Fluid Bicarbonate Composition | 5, 10, 15, and 20-minutes post-secretin administration | A primary outcome will be the bicarbonate level (milliequivalent per liter) in the pancreatic fluid collected. |
| Pancreatic Fluid Sodium Composition | 5, 10, 15, and 20-minutes post-secretin administration | A primary outcome will be the sodium level (milliequivalent per liter) in the pancreatic fluid collected. |
| Pancreatic Fluid Potassium Composition | 5, 10, 15, and 20-minutes post-secretin administration | A primary outcome will be the potassium level (milliequivalent per liter) in the pancreatic fluid collected. |
| Pancreatic Fluid Chloride Composition | 5, 10, 15, and 20-minutes post-secretin administration | A primary outcome will be the chloride level (milliequivalent per liter) in the pancreatic fluid collected. |
Countries
United States
Contacts
CONTACTLiz Lemke
CONTACTSamuel Han, MD
PRINCIPAL_INVESTIGATORSamuel Han, MD
Mayo Clinic
Outcome results
None listed