Helicobacter Pylori Infection
Conditions
Keywords
Helicobacter pylori, quadruple therapy
Brief summary
Bismuth-containing quadruple therapy was recommended as a first-line treatment for Helicobacter pylori infection. This study aimed to compare real-world outcomes of various potassium-competitive acid blockers (P-CABs) -based bismuth quadruple regimens and identify factors influencing treatment failure. A multicenter cohort study was conducted and study outcomes included eradication rates and incidence of adverse events.
Interventions
OTHERDoctors prescribe Helicobacter pylori treatment regimens for patients based on current guidelines and consensus statements, tailored to individual circumstances，not involve any intervention procedures
Doctors prescribe Helicobacter pylori treatment regimens for patients based on current guidelines and consensus statements, tailored to individual circumstances，not involve any intervention procedures.
Sponsors
Qilu Hospital of Shandong University
Feicheng People's Hospital
Binzhou Maternal and Child Health Hospital
Jinxiang County People's Hospital
The People's Hospital of Jimo
Zibo Maternal and Child Health Hospital
Yantai Penglai Traditional Chinese Medicine Hospital
Zaozhuang Municipal Hospital
Linyi Yizhou Hospital
Taierzhuang District People's Hospital
Shandong University of Traditional Chinese Medicine
Yuncheng Traditional Chinese Medicine Hospital
Caoxian County Hospital
Qihe County People's Hospital
University Town Hospital, Affiliated Hospital of Shandong University of Traditional Chinese Medicine
Dezhou Hospital Qilu Hospital of Shandong University
The 2nd People's Hospital of Dongying City
Zhangdian District Hospital of Traditional Chinese Medicine
Yantai Zhifu Hospital
Inner Mongolia Autonomous Region International Mongolian Medicine Hospital
Hohhot Second Hospital
Guanxian People's Hospital
Longkou People's Hospital
Linshu County Hospital of Traditional Chinese Medicine
Yueyue Li
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* patients aged 18-70 years, regardless of gender; * willing to receive H. pylori eradication therapy; * diagnosed with H. pylori infection through at least one of the following methods: rapid urease test, ¹³C/¹⁴C-urea breath test, or histopathological examination.
Exclusion criteria
* patients with incomplete medical records, including missing treatment details, absence of post-treatment follow-up test results, or failure to complete essential follow-up assessments; * patients who received treatment regimens that did not comply with the quadruple regimens specified in this study.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Eradication rate | 6-8 weeks after treatment completion | Comparison of eradication rates among quadruple therapies for Helicobacter pylori |
Secondary
| Measure | Time frame |
|---|---|
| Adverse events | lmmediately after treatment completion |
Countries
China
Contacts
Primary ContactYueyue Li
Outcome results
None listed