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MUSCLE-ML: Multimodal Integration of Muscle Strength, Structure by Machine Learning for Precision Rehabilitation After ACL Injury

MUSCLE-ML: Multimodal Integration of Muscle Strength, Structure by Machine Learning for Precision Rehabilitation After ACL Injury

Status
Not yet recruiting
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT07284771
Enrollment
182
Registered
2025-12-16
Start date
2026-04-01
Completion date
2028-08-31
Last updated
2025-12-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Machine Learning

Brief summary

The goal of this clinical trial is to use machine learning (ML) to predict functional recovery by integrating muscle-related factors and other relevant parameters for identification of non-responders to conventional rehabilitation. The main questions it aims to answer are: Do deficit clusters lead to poorer functional recovery compared to non-deficit clusters? Does an ML-derived composite score that integrates quadriceps/hamstring strength and size outperform isolated metrics in predicting RTP success? Researchers will compare deficit clusters against non-deficit clusters to determine if deficit clusters lead to poorer functional recovery. Participants will: Return for 5 follow-up timepoints in total for PRO and functional assessments including pre-operation, 1-, 3-, 6- and 12-months post-operation.

Interventions

OTHERNo Intervention: Observational Cohort

no intervention

Sponsors

Chinese University of Hong Kong
Lead SponsorOTHER

Study design

Observational model
COHORT
Time perspective
PROSPECTIVE

Eligibility

Sex/Gender
ALL
Healthy volunteers
Yes

Inclusion criteria

* Unilateral ACL injury and plan for ACLR * Commit the post-operation physiotherapy in Prince of Wales Hospital

Exclusion criteria

* Preoperative radiographic signs of arthritis * Patient non-compliance to the rehabilitation program

Design outcomes

Primary

MeasureTime frame
International Knee Documentation Committee score6- and 12-months post-operation

Contacts

Primary Contactmuriel XIAO
lingqingxiao@cuhk.edu.hk(852)35053311

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026