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Effect of High-intensity Interval Training on Cardiometabolic Health and Physical Fitness in Young Adults With Obesity

Effect of High-intensity Interval Training on Cardiometabolic Health and Physical Fitness in Young Adults With Obesity

Status
Enrolling by invitation
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT07283406
Enrollment
40
Registered
2025-12-15
Start date
2026-01-03
Completion date
2026-04-30
Last updated
2025-12-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Obesity & Overweight

Keywords

obesity, HIIT, MICT

Brief summary

The objective of the present project is to compare the effects of two types of training on cardiovascular health components and physical fitness in young adults with obesity.

Detailed description

Obesity represents a serious public health problem, and its prevalence continues to rise worldwide. Numerous studies have documented the positive effects of moderate-intensity continuous training (MICT) on cardiovascular and metabolic health in individuals living with obesity; however, the effects of high-intensity interval training (HIIT) are still being explored. Therefore, the objective of the present research protocol is to analyze and compare the effects of an MICT program and an HIIT program on cardiometabolic biomarkers and physical fitness in young adults with obesity.

Interventions

The HIIT group will undergo training for 12 weeks, with a frequency of three sessions per week, completing a total of 36 sessions. Each session will include a 5-minute warm-up and a 5-minute cool-down at 50-60% of maximum heart rate (HRmax). The training protocol will consist of 2-minute high-intensity intervals performed at 90-95% HRmax, corresponding to a Borg rating of perceived exertion (RPE) of 17-18, alternated with 2-minute recovery periods at 70% HRmax (RPE 12-14). A total of five intervals will be completed per session, resulting in an overall high-intensity workload of 18 minutes. All training sessions will be conducted on a stationary cycle ergometer

OTHERModerate-intensity continuous training intervention

The MICT group will perform moderate-intensity continuous training at 60-70% HRmax, corresponding to an RPE of 12-14, for 35-45 minutes on a stationary cycleergometer. Heart rate and physical activity levels will be continuously monitored in both groups using a chest-strap heart rate sensor (Polar H9, Polar Electro, Finland).

In addition, four educational sessions will be conducted to provide dietary recommendations to all participants. These sessions will aim to promote balanced eating habits and to discourage the excessive consumption of ultra-processed foods or alcohol, as these factors could interfere with the intervention outcomes.

Sponsors

Centro Universitario de Tlajomulco, Universidad de Guadalajara
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE

Eligibility

Sex/Gender
ALL
Age
18 Years to 35 Years
Healthy volunteers
No

Inclusion criteria

* Young adults * BMI ≥ 30 kg/m\^2 and \< 40 kg/m\^2 * Signed informed consent form

Exclusion criteria

* Participants who smoke * Clinical diagnosis of hypothyroidism * Clinical diagnosis of type 1 diabetes mellitus * Clinical diagnosis of type 2 diabetes mellitus * Clinical diagnosis of grade 3 obesity * Clinical diagnosis of hypertension * Clinical diagnosis of acute myocardial infarction or angina pectoris * Use of nitrates and calcium channel blockers within 4 days prior to the start of the study * Use of beta-blockers or hypoglycemic agents within 7 days prior to the intervention * Pregnant women * Breastfeeding women * Men consuming more than 40 g of alcohol per day or women consuming more than 20 g per day * Postural and biomechanical disorders (knee, foot, and spine)

Design outcomes

Primary

MeasureTime frameDescription
C-reactive protein (CRP)Baseline and after 12 weeksCRP (mg/dl): Changes from baseline to 12 weeks of intervention
Maximum oxygen uptake (VO₂max)Baseline and after 12 weeksVO₂max (ml/min/kg): Change from Baseline at 12 weeks, measured using a submaximal exercise test based on the Åstrand-Ryhming protocol
WeightBaseline and after 12 weeksWeight (kg): Changes in weight from baseline to 12 weeks of intervention.
HeightBaseline and after 12 weeksHeight (cm): Changes in height from baseline to 12 weeks of intervention.
Body mass index (BMI)Baseline and after 12 weeksBMI (kg/m2): Change from Baseline at 12 weeks, calculated by: weight (kg)/ height (m\^2)
Body fat percentageBaseline and after 12 weeksBody fat percentage (%): Changes in body fat assessed by bioelectrical impedance analysis (BIA)
Muscle mass percentageBaseline and after 12 weeksMuscle mass percentage (%): Changes in muscle mass measured using bioelectrical impedance analysis (BIA)
Waist circumferenceBaseline and after 12 weeksWaist circumference (cm): Changes in waist circumference will be measured using a Lufkin measuring tape (USA) following the guidelines of the International Society for the Advancement of Kinanthropometry (ISAK)
Waist-to-hip ratioBaseline and after 12 weeksWaist-to-hip ratio: Changes in waist-to-hip ratio will be calculated by dividing the waist measurement by the hip measurement
GlucoseBaseline and after 12 weeksGlucose (mg/dl): Changes from baseline to 12 weeks of intervention
TriglyceridesBaseline and after 12 weeksTriglycerides (mg/dl): Changes from baseline to 12 weeks of intervention
Total cholesterolBaseline and after 12 weeksTotal cholesterol (mg/dl): Changes from baseline to 12 weeks of intervention
HDL cholesterolBaseline and after 12 weeksHDL cholesterol (mg/dl): Changes from baseline to 12 weeks of intervention
LDL cholesterolBaseline and after 12 weeksLDL cholesterol (mg/dl): Changes from baseline to 12 weeks of intervention
Systolic blood pressure (SBP)Baseline and after 12 weeksSBP (mmHg): Changes from baseline to 12 weeks of intervention
Diastolic blood pressure (DBP)Baseline and after 12 weeksDBP (mmHg): Changes from baseline to 12 weeks of intervention

Countries

Mexico

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026