Peripheral Artery Disease
Conditions
Keywords
Obstructive Sleep Apnea Syndrome, Polygraphy, Diagnosis, Prevalence, Peripheral Arterial Occlusive Disease
Brief summary
Obstructive sleep apnea syndrome (OSAS) is characterized by partial (hypopnea) or complete (apnea) obstruction of the upper airways, leading to intermittent hypoxemia and sleep fragmentation. Peripheral arterial occlusive disease (PAOD) is a chronic condition defined by the narrowing or occlusion of arteries in the lower limbs, often resulting in ischemia of downstream tissues. This disease is a common complication of atherosclerosis and affects approximately 1.2% of the general French population. OSAS is a well-established risk factor for atherosclerotic disease, particularly for coronary and neurovascular events. Although a relationship between OSAS and PAOD has been investigated in recent years, the link has not been definitively established and requires further study. Therefore, this preliminary cohort study aims to observe the prevalence of OSAS among patients diagnosed with PAOD, regardless of the disease stage.
Interventions
None listed
Sponsors
Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. Age ≥ 18 years 2. Patients with a confirmed diagnosis of PAOD, seen either during hospitalization or in an outpatient vascular medicine consultation. Inclusion is permitted regardless of the disease stage (according to the Leriche and Fontaine classification) or prior surgical intervention. 3. No objection to the use of their pseudonymised medical data 4. Polygraphy scheduled as part of routine care within one month.
Exclusion criteria
1. Inability to perform the Ankle-Brachial Index (ABI) or sleep polygraphy due to physical or cognitive constraints (e.g., severe dementia, limb malformation, etc.). 2. History of OSAS diagnosis confirmed by polygraphy, and currently receiving nocturnal treatment (e.g., Continuous Positive Airway Pressure - CPAP)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Proportion of patients diagnosed with OSAS | Up to 1 month | Patients diagnosed with OSAS by polygraphy, regardless of severity. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Proportion of patients diagnosed with OSAS, stratified by the presence or absence of cardiovascular comorbidities. | Up to 1 month | The prevalence of OSAS will be analyzed in patients with PAOD, stratified by the presence or absence of cardiovascular involvement (e.g., carotid plaque, carotid stenosis, or abdominal aortic aneurysm). |
| Ankle-brachial index | Day 0 | The Ankle-Brachial Index (ABI) will be analyzed according to OSAS severity, which is defined by the Apnea-Hypopnea Index (AHI): * Mild: 5 to 14 events per hour * Moderate: 15 to 30 events per hour * Severe: \> 30 events per hour |
| Toe-brachial index | Day 0 | The toe-Brachial Index (TBI) will be analyzed according to OSAS severity, which is defined by the Apnea-Hypopnea Index (AHI): * Mild: 5 to 14 events per hour * Moderate: 15 to 30 events per hour * Severe: \> 30 events per hour |
| Proportion of patients diagnosed with OSAS according to PAOD severity | Up to 1 month | The prevalence of OSAS (diagnosed by polygraphy) will be analyzed according to the severity stage of PAOD. |
Countries
France
Contacts
CONTACTLéonie GEY, M.D.
STUDY_DIRECTORLéonie GEY, M.D.
Centre Hospitalier Intercommunal Toulon La Seyne sur Mer
Outcome results
None listed