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Comparison of the Pain Levels of Single-Dose Premedication With Piroxicam and Prednisolone on Post-Endodontic Pain in Single-Visit Root Canal Treatment of Premolars

Comparison of the Pain Levels of Single-Dose Premedication With Piroxicam and Prednisolone on Post-Endodontic Pain in Single-Visit Root Canal Treatment of Premolars

Status
Not yet recruiting
Phases
Phase 4
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT07281807
Enrollment
60
Registered
2025-12-15
Start date
2026-01-01
Completion date
2027-01-31
Last updated
2025-12-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Irreversible Pulpitis With Apical Periodontitis, Symptomatic Apical Periodontitis

Brief summary

To compare the post operative mean pain scores by administering single-dose preoperative piroxicam and prednisolone in patients of irreversible pulpitis with symptomatic apical periodontitis.

Interventions

DRUGGroup B: patients will be given prednisolone 20mg as premedication

Group B: patients will be given prednisolone 20mg as premedication

DRUGpiroxicam 20mg

Group A: patients will be given piroxicam 20mg as premedication

Sponsors

RANA AHMAD
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Caregiver)

Eligibility

Sex/Gender
ALL
Age
18 Years to 40 Years
Healthy volunteers
Yes

Inclusion criteria

* Healthy patient ranging between 18-40 years * Having at least one premolar with diagnosis of symptomatic irreversible pulpitis according to history, examination and radiographs. * Teeth having mature apex confirmed by periapical radiographs.

Exclusion criteria

* History of systemic disorders including HIV, Hepatitis * Pregnancy (As per Medical record/ Verbally) * Patient using medication such as analgesics or anti-inflammatory drugs * Patient allergic to lignocaine, piroxicam and prednisolone * Tooth not suitable for restoration * Periodontal probing depth ≥ 4mm * Retreatment cases * Patients having calcified canals assessed by radiographic findings

Design outcomes

Primary

MeasureTime frameDescription
pain after single visit root canal treatment48 hourspain score on visual analogue scale

Contacts

Primary Contactrana ahmad, B.D.S., F.C.P.S.
ranam_ahmad@hotmail.com+923335990799

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026