Papilla Reconstruction
Conditions
Keywords
Papilla, Reconstruction, Hyaluronic Acid, Injectable Platelet Rich Fibrin, Microneedling
Brief summary
This randomized split-mouth clinical trial aims to compare the clinical effectiveness of microneedling combined with injectable platelet-rich fibrin (i-PRF) versus hyaluronic acid (HA) gel injection in the reconstruction of Class I interdental papilla loss. The study hypothesizes that MN + i-PRF will yield greater papillary regeneration, offering a minimally invasive, biologically active alternative to traditional surgical approaches for soft-tissue esthetic rehabilitation.
Interventions
BIOLOGICALInjectable Platelet Rich Fibrin
Injectable Platelet Rich Fibrin
OTHERHyaluronic Acid (HA)
Filler
Sponsors
King Abdulaziz University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to 45 Years
Healthy volunteers
No
Inclusion criteria
* Plaque index \<1 * Gingival index \<1 * Class I papillary loss (Nordland and Tarnow classification) * Probing depth ≤4 mm at the test site * Inter-proximal bone crest distance ≤7 mm from the contact point.
Exclusion criteria
* Pregnancy * Lactation * Uncontrolled systemic diseases (e.g., diabetes) * Anticoagulant therapy * Recent radiotherapy * Orthodontic treatment * Midline diastema * High frenum attachment * Class II/III papillary loss.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Papillary height | Baseline, 6 weeks, and 12 weeks. | from the mucogingival junction to the papilla tip |
| Papillary width | 12 weeks | — |
Countries
Saudi Arabia
Outcome results
None listed