Bladder (Urothelial, Transitional Cell) Cancer, Distilled Water, Hypertonic Saline, Irrigation, Nonmuscle Invasive Bladder Cancer, Normal Saline
Conditions
Brief summary
This randomized controlled trial will evaluate the efficacy of three bladder irrigation solutions - distilled water (DW), normal saline (NS), and hypertonic saline (HS) - as continuous bladder irrigation (CBI) following transurethral resection of non-muscle invasive bladder cancer (NMIBC). Short term (6 months) recurrence and progression free survival are mainly evaluated.
Interventions
DRUGContinuous Bladder Irrigation with distilled water
Continuous Bladder Irrigation with distilled water post non muscle invasive bladder cancer urethral resection by endoscopy
DRUGContinuous Bladder Irrigation with normal saline
Continuous Bladder Irrigation with normal saline post non muscle invasive bladder cancer urethral resection by endoscopy
DRUGContinuous Bladder Irrigation with hypertonic saline
Continuous Bladder Irrigation with hypertonic saline post non muscle invasive bladder cancer urethral resection by endoscopy
Sponsors
Ain Shams University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Caregiver)
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* Patients of non-muscle invasive urinary bladder urothelial carcinoma amenable for complete resection
Exclusion criteria
* Patients with post-operative complications that need prolonged irrigation. * Patient who underwent incomplete resection during TURBT. * When large bladder perforation was suspected during TURBT. * Patients with chronic kidney disease. * Muscle invasive disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Risk of Recurrence | 6 months |
| Risk of progression of bladder cancer | 6 months |
Countries
Egypt
Outcome results
None listed