Analysis of The Outcomes of Therapeutic Photorefractive Keratectomy Combined With Prophylactic Accelerated Cross-Linking (PRK-Plus), for Treatment of Thin Suspicious Cornea

Analysis of The Outcomes of Therapeutic Photorefractive Keratectomy Combined With Prophylactic Accelerated Cross-Linking (PRK-Plus), for Treatment of Thin Suspicious Cornea: Short-Term Pilot Study

Status

Not yet recruiting

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT07277348

Enrollment

Registered

2025-12-11

Start date

2026-02-01

Completion date

2027-03-01

Last updated

2025-12-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Thin Suspicious Cornea

Brief summary

analyze the outcomes of therapeutic photorefractive keratectomy combined with prophylactic accelerated cross-linking (PRK-Plus), for treatment of thin suspicious cornea

Interventions

PROCEDUREPRK PLUS

therapeutic photorefractive keratectomy combined with prophylactic accelerated cross-linking

Study design

Allocation

NON_RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 40 Years

Healthy volunteers

Inclusion criteria

1. CCT less than 490 microns 2. K mean more than 46 and/or K max more than 47. 3. Astigmatism cylinder \>1.5 D. 4. D value of Belin/Ambrósio Module \> 1.6 5. inferior- superior asymmetry or bow-tie pattern with skewed radial axes on tangential maps and abnormal changes on (BAD). 6. Asymmetry topography between 2 eyes, even if neither eyes topographic pattern is in itself decidedly abnormal. 7. Any significant skewed radial axis with or without inferior steepening, or one diopter or more of inferior steepening in some areas but an I-S value of ,1.4,7. 8. young patients with against-the-rule astigmatic patterns. 9. a PTA value 40% if calculated. 10. Abnormal Topographic Patterns 11. K2 reading of corneal back surface less than \[-7\]. 12. D Value of CSTP \> 2.5 in Belin/Ambrósio curve 13. We look at values within the central 5 mm circle; the map should be displayed in the BFTE float mode with an estimated area of 8 mm of diameter: * Elevation values on the front surface values \> +12 μ * Elevation values on the back surface values \>+15 μ. * If there is any isolated island on either front or back surfaces (in the BFS float mode)

Exclusion criteria

1. Eyes diagnosed with KC. 2. CCT less than 450 microns

Design outcomes

Primary

Measure	Time frame	Description
visual acuity improvement measured by LogMAR system	1 year	visual acuity improvement measured by LogMAR system

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026