Central Haemodynamics and Pacing for AV Block

The Pacing in Atrioventricular Block: a Comparative Evaluation of Central Haemodynamics, Cardiac Function, and Quality of Life

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT07276490

Acronym

PACE-CCQ

Enrollment

124

Registered

2025-12-11

Start date

2025-11-28

Completion date

2027-12-31

Last updated

2026-03-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Atrioventricular Block, Conduction System Pacing, Pacing Therapy, Right Ventricular Pacing

Keywords

conduction system pacing, atrioventricular block, right ventricular pacing

Brief summary

A randomized, single-blind study comparing two pacing strategies in patients with atrioventricular block requiring permanent pacemaker implantation. This trial evaluates the impact of conduction system pacing (left bundle branch area pacing) versus standard right ventricular pacing on central hemodynamics, cardiac function, and patient quality of life over 12 months. The study will enroll 124 patients from two Estonian tertiary hospitals and measure central systolic arterial pressure as the primary outcome, with secondary assessments of arterial stiffness, echocardiographic parameters, electrical activation patterns, and quality of life scores.

Interventions

DEVICERight ventricular pacing

Pacemaker implantation with RV lead placement

DEVICEConduction system pacing

Pacemaker implantation with conduction system (LBBAP) lead placement

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

SINGLE (Subject)

Eligibility

Sex/Gender

ALL

Age

18 Years to 80 Years

Healthy volunteers

Inclusion criteria

* Age 18-80 years * Diagnosis of atrioventricular block * Expected survival \>1 year

Exclusion criteria

* Reduced left ventricular ejection fraction (EF \<45%) * Expected ventricular pacing burden \<20% * Inter-arm systolic blood pressure difference \>15 mmHg * Percutaneous coronary intervention or coronary artery bypass surgery within the last 30 days * Secondary hypertension * Orthostatic hypotension * Clinically significant valvular heart disease * Congenital heart disease * Pulse wave analysis or pulse wave velocity measurement cannot be reliably performed * Pregnancy or breastfeeding * Withdrawal of consent by the subject * Loss of contact during the study

Design outcomes

Primary

Measure	Time frame
Central systolic blood pressure	One year post implantation of pacemaker

Countries

Estonia

Contacts

CONTACTSilver Heinsar, MD, PhD

silver.heinsar@ut.ee+372 5333 1997

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 10, 2026