Acute Exacerbation of Asthma
Conditions
Brief summary
Because of insufficient local comparative data, this study was designed to determine the outcome of intravenous dexamethasone in contrast to oral prednisolone in acute exacerbation of asthmatic children.
Detailed description
The findings of this study would furnish the local data. The results would also provide recommendations to use more appropriate steroid options in the local settings, resulting in aid to improve the quality of life of asthmatic children and their quicker return to daily routine activities.
Interventions
DRUGDexamethasone
Patients received single IV dose of Dexamethasone at a dose of 0.6 mg/kg
DRUGPrednisolone
Patients received oral prednisone at a dose of 2 mg/kg/day (max 60 mg) as a single dose for 3 days.
Sponsors
Muhammad Aamir Latif
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
2 Years to 12 Years
Healthy volunteers
No
Inclusion criteria
* Children of any gender * Aged 2-12 years * Presenting with acute exacerbation of asthma within 24-hours
Exclusion criteria
* Children with PRAM score of ≥ 10 * Used oral or parenteral corticosteroids in last 4-weeks * With any chronic condition of lungs (TB, cystic fibrosis), liver (chronic liver disease), kidneys (chronic kidney disease, nephrotic syndrome) or blood (thalassemia, malignancy)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Asthma exacerbation | 4 days | The Pediatric Respiratory Assessment Measure (PRAM) score was used to assess the severity of asthma exacerbation. This score consisted of 5 items and had a maximum score of 12: suprasternal retractions (0-2), scalene muscle contraction (0-2), air entry in chest (0-3), wheeze (0-3), and oxygen saturation (0-2). A score of 1-3 showed mild exacerbation, 4-7 showed moderate exacerbation, and 8-12 revealed severe exacerbation of asthma. |
Countries
Pakistan
Outcome results
None listed