Incidence, Treatment and Outcome After Acute Mesenteric Ischemia in the Region of Västra Götaland, 2000-2023.

Incidence, Treatment of and Outcome of Acute Mesenteric Ischemia in the Region of Västra Götaland, 2000-2023 - a Retrospective Observational Study

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT07274306

Acronym

AMIGO

Enrollment

2446

Registered

2025-12-10

Start date

2025-02-24

Completion date

2026-01-31

Last updated

2025-12-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Mesenteric Artery Ischemia

Keywords

Acute mesenteric ischemia, Mesenteric ischemia, Intestinal ischemia, Population-based cohort, Epidemiology, Incidence, Mortality, Mesenteric arterial occlusion, Sweden / Västra Götaland

Brief summary

The goal of this retrospective observational study is to describe the incidence and outcome of patients diagnosed with acute mesenteric ischemia (AMI) in the Västra Götaland region of Sweden between 2000-2023. The main questions it aims to answer are: * What was the observed incidence and outcome, and how did it change during the time period? * How did socioeconomic factors influence incidence and outcome of AMI? * What main surgical approaches were selected for these patients? * What was the distribution of anticoagulant use in the cohort, and what effect did the introduction of new oral anticoagulants (NOAC) have on incidence and mortality in AMI? * What was the prevalence of Short Bowel Syndrome (SBS) after surgical intervention? Participants were obtained from the regional diagnosis registry. Additional datapoints were obtained from the Swedish statistics bureau and pharmaceutical registers.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Inclusion criteria

* all patients discharged from hospital with acute mesenteric ischemia (ICD K55.0 and K55.9)

Exclusion criteria

Design outcomes

Primary

Measure	Time frame	Description
Incidence of acute mesenteric ischemia	Year 2000-2023	Annual incidence rate of acute mesenteric ischemia per 100,000 person-years in the Västra Götaland region.
Mortality from acute mesenteric ischemia	30 days, 90 days, 1 year.	All-cause mortality within up to 1 year of AMI diagnosis.

Secondary

Measure	Time frame	Description
Surgical management strategy	Year 2000-2023	Proportion of patients undergoing bowel resection, revascularization (open or endovascular), or non-operative management.
Socioeconomic determinants of incidence and outcome	Year 2000-2023	Association between SES indicators (income, education, immigration status, geographic distance to care) and risk of AMI or mortality.
Anticoagulant use patterns	At AMI diagnosis; trends from 2000-2023	Proportion of patients using vitamin-K antagonists, NOACs, antiplatelet therapy, or no anticoagulation; association with incidence and survival.
Prevalence of Short Bowel Syndrome (SBS)	Within 1 year of surgical intervention	Number and percentage of patients developing SBS (ICD-10 K91.2 and K90.8) after AMI.
Temporal trends in incidence and mortality	Year 2000-2023	Change over time in incidence and mortality, including before and after introduction of non-vitamin K antagonist oral anticoagulants (NOACs).

Countries

Sweden

Outcome results