Fluid Refractory Septic Shock, Septic Shock
Conditions
Keywords
Septic Shock, Adrenaine, Dopamine, Fluid refractory septic shock
Brief summary
This study compares the efficacy of two drugs i.e Adrenaline and dopamine in fluid refractory type of septic shock which is a dreadful medical condition especially in children. The efficacy will be checked based on heart rate , GCS, capillary refill time , palpable pripheral pulse , urine output and systolic blood pressure.
Detailed description
This is a randomized control trial in which children / patients diagnosed with Fluid refractory Septic shock will be provided with one of the two drugs ina randomzied way and their efficacy will be assesed on the basis of correction of various parameters at various points of time.
Interventions
DRUGAdrenaline
The adrenaline will be given as a vasoconstrictor in the dose of 0.1-0.3ug/kg/min to the patients in group A when diagnosed with fluid refractory septic shock
DRUGDopamine
The drug dopamine will be adminitered in dose of 10-20ug/kg/min to the patients of group B when diagnosed with fluid refractory septic shock.
Sponsors
Laiba Qamar
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
1 Months to 12 Months
Healthy volunteers
No
Inclusion criteria
Patients of both Genders having age range between 1month and 12 years with diagnosis of fluid refractory septic shock as per operational definition. \-
Exclusion criteria
* Patients with 1. cardiopumonary Bypass during last 5 days 2. Chronic Systemic disease like Chronic kidney Disease , cerebral palsy, congenital heart disease 3. neuromuscular discorder 4. Metabolic disorders 5. Those who already had treatment at periphery for hypovolemia without any record of medication or sequential organ failure at presentation
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Blood Pressure | 6 hours | The blood pressure of the patients will be meaures after administration of each drug at 20 mins and 6 hours. |
| Pulse | 6 hours | The pulse will be compared after adminitration of both drugs at 20 mins and 6 hours |
| Capillary Refill Time | 6 Hours | Capillary Refill time will be assessed after administration of each drug at 20 mins and 6 hours |
| Urine output | 6 hours | Urine output will be calculated from the time of administration of each drug at 20mins and 6 hours and comapred. |
| GCS | 6 hours | Glascow Comma Scale (GCS) will be asses at 20 mins and 6 hours after administration of each drug |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| SOFA ( Sequential Organ Failure Assesment) | 6 Hours | SOFA ( Sequential Organ Failure Assesment) score will be calculated afte adminitration of each drug at 20mins and 6 hours |
Countries
Pakistan
Contacts
Primary ContactHafiz Muhammad Abdullah Dr, MBBS
Outcome results
None listed