Adult Patients Undergoing CABG
Conditions
Brief summary
The primary objective of this study is to determine the feasibility of preoperative stellate ganglion block in reducing the incidence of postoperative atrial fibrillation in patients undergoing CABG.
Interventions
PROCEDUREStellate Ganglion Block
Ultrasound-guided stellate ganglion block with ropivacaine
Sponsors
Xijing Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
DOUBLE (Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* more than 18 years old * undergoing CABG * Provide informed consent
Exclusion criteria
* History of prior cardiac surgery or atrial fibrillation ablation; * Emergency coronary artery bypass grafting (CABG); * Concomitant cardiac procedures (e.g., congenital heart disease repair, left ventricular reconstruction, valve surgery, or aortic surgery); * Critical preoperative status requiring mechanical or pharmacological support before CABG; * Left ventricular ejection fraction (LVEF) \<35%; * History of atrial fibrillation (defined as a supraventricular tachyarrhythmia characterized by rapid and irregular atrial electrical activity); * Significant mitral valve disease (mitral valve area \<1.5 cm² or regurgitant jet area \<4 cm²), significant aortic valve disease (valve area \<1.5 cm² or regurgitant jet-to-left ventricular outflow tract ratio \>25%); * Severe left atrial enlargement (left atrial anteroposterior diameter \>55 mm); * Poorly controlled hyperthyroidism; * Conditions requiring radiotherapy, chemotherapy, or long-term hormonal therapy; * Patients with known clinical contraindications to stellate ganglion block (SGB).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| postoperative atrial fibrillation（POAF） | within 7 days postoperatively |
Secondary
| Measure | Time frame |
|---|---|
| cumulative time spent in postoperative atrial fibrillation | within 7 days postoperatively |
| the need for antiarrhythmic medications to treat postoperative atrial fibrillation | within 7 days postoperatively |
| the need for systemic anticoagulation due to postoperative atrial fibrillation | within 7 days postoperatively |
| the need for postoperative electrical cardioversion | within 7 days postoperatively |
| the duration of postoperative in-hospital stay | duration of postoperative hospital stay |
| number of POAF | within 7 days postoperatively |
Countries
China
Outcome results
None listed