Atrial Fibrillation
Conditions
Brief summary
The primary objective of this observational study is to evaluate whether magnetocardiography (MCG) findings more accurately predict clinical outcomes in patients with acquired Long QT syndrome compared to ECG. The secondary objective is to assess differences in QT interval length between MCG and ECG. The primary safety objective is to characterize the safety profile of the CardiAQ MCG device.
Interventions
DIAGNOSTIC_TESTMagnetocardiography
MCG is a non-invasive, radiation-free imaging technique that detects the magnetic field generated by the electrical activity of the heart.
Sponsors
Mayo Clinic
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. Age ≥ 18 years on the date of consent 2. Ability for participant to comply with study requirements 3. Written informed consent 4. Confirmed diagnosis of atrial fibrillation and receiving dofetilide for rhythm control in the inpatient setting.
Exclusion criteria
1. Pregnant or breastfeeding 2. Active thoracic metal implants (including pacemaker, insertable cardiac monitor, or internal defibrillators). 3. External electrical pads or devices (e.g. Pacer pads, ECG electrodes, heart rate patch), that must remain on patient's chest during MCG scan 4. Inability to lie down in a supine/inclined position and stay still on the examination bed 5. Clinical conditions that in the opinion of the Investigator would compromise the safety of the patient or ability to complete the protocol
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Number of successful dofetilide loading using Magnetocardiography | Baseline | Dofetilide loading is considered successful if the following conditions are met: 1. No excessive QTc prolongation QTc remains \<500 ms, and no \>15% increase from baseline. 2. No sustained VT or recurrent/symptomatic non-sustained VT (NSVT) suggestive of proarrhythmia. 3. No symptomatic bradycardia or hemodynamic instability 4. Stable renal function 5. No deterioration necessitating dose reduction or discontinuation. 6. Discharge on a stable dose |
| Number of successful dofetilide loading using Electrocardiogram | Baseline | Dofetilide loading is considered successful if the following conditions are met: 1. No excessive QTc prolongation QTc remains \<500 ms, and no \>15% increase from baseline. 2. No sustained VT or recurrent/symptomatic non-sustained VT (NSVT) suggestive of proarrhythmia. 3. No symptomatic bradycardia or hemodynamic instability 4. Stable renal function 5. No deterioration necessitating dose reduction or discontinuation. 6. Discharge on a stable dose |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Electrocardiogram - QT interval length | Baseline | QT interval length is a measurement from the start of the Q wave to the end of the T wave. This will be measured in seconds. |
| Magnetocardiography - QT interval length | Baseline | QT interval length is a measurement from the start of the Q wave to the end of the T wave. This will be measured in seconds. |
Countries
United States
Contacts
CONTACTPatsy Caceres Figueroa
PRINCIPAL_INVESTIGATORMohamad Alkhouli, M.D., M.B.A.
Mayo Clinic
Outcome results
None listed