Anterior Cruciate Ligament Injury
Conditions
Brief summary
No local data exists regarding the outcomes of anterior cruciate ligament reconstruction by hamstring graft with and without platelet-rich plasma. This study aimed to compare the functional outcomes of arthroscopic anterior cruciate ligament reconstruction by hamstring graft with and without platelet-rich plasma.
Detailed description
In animal studies, platelet-rich plasma has shown excellent results in accelerating the healing of the anterior cruciate ligament, but studies on human have shown varying clinical outcomes when investigating platelet-rich plasma for its effects on anterior cruciate ligament reconstruction. The findings of this study could provide important insights about the possible role of platelet-rich plasma in arthroscopic anterior cruciate ligament reconstruction by hamstring graft. to enhance early graft healing and reduce early complications, though its long-term effectiveness remains inconsistent. Studies suggest PRP may improve short-to-medium term outcomes like reduced pain and enhanced knee function,
Interventions
PROCEDUREACL reconstruction by hamstring graft with PRP
Patients underwent anterior cruciate ligament reconstruction by hamstring graft along with platelet-rich plasma augmentation applying the standard arthroscopic ACL reconstruction technique.
PROCEDUREACL reconstruction by hamstring graft
Patients underwent anterior cruciate ligament reconstruction by hamstring graft without platelet-rich plasma augmentation applying the standard arthroscopic ACL reconstruction technique.
Sponsors
Muhammad Aamir Latif
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 40 Years
Healthy volunteers
No
Inclusion criteria
* Any gender * Aged 18-40 years * With clinically and radiologically confirmed arthroscopic evidence of ACL injury
Exclusion criteria
* With comprised bilateral ACL tears * Lack of fitness due to associated comorbidity * Fractures of lower limb bones and/or spine/neurovascular injuries * Injuries to other knee ligaments * Significant knee joint arthritis * Local skin infections
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Anterior Drawer's test | 12 weeks | Number of patients having grade-1 on the Anterior Drawer's test |
| Lachman's test | 12 weeks | Number of patients having grade-1 on the Lysholm knee score |
| Lysholm knee score | 12 weeks | A higher Lysholm knee score was labeled as effectiveness of the treatment. |
Countries
Pakistan
Outcome results
None listed