Chronic Liver Disease and Cirrhosis
Conditions
Brief summary
Liver Transplantation (LT) is a lifesaving intervention with around 90% of recipients currently surviving the first postoperative year and subsequent life expectancy now exceeding 20 years. After the post-operative recovery period, however, LT recipients become more and more confronted with the challenges of re-engagement with life after transplantation, a need to reach a new stability, reestablish function in everyday life, reconnect with valued roles, regain independence, and resume work Sexual function is a very important parameter in the evaluation of Quality of Life (QoL), as it has been shown that sexual dysfunction in transplant patients is associated with increased depression and decreased QoL. There are several studies in the relevant literature supporting the recovery of sexual function in patients after liver transplantation. It has been found that recovery was observed in erectile dysfunction in male patients 6 months after liver transplantation.
Detailed description
Liver Transplantation (LT) is a lifesaving intervention with around 90% of recipients currently surviving the first postoperative year and subsequent life expectancy now exceeding 20 years. After the post-operative recovery period, however, LT recipients become more and more confronted with the challenges of re-engagement with life after transplantation, a need to reach a new stability, reestablish function in everyday life, reconnect with valued roles, regain independence, and resume work Sexual function is a very important parameter in the evaluation of Quality of Life (QoL), as it has been shown that sexual dysfunction in transplant patients is associated with increased depression and decreased QoL. There are several studies in the relevant literature supporting the recovery of sexual function in patients after liver transplantation. It has been found that recovery was observed in erectile dysfunction in male patients 6 months after LT
Interventions
OTHERNo Treatment
This is an Observational Study
Sponsors
Institute of Liver and Biliary Sciences, India
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
MALE
Age
18 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
1. Married male Patients. 2. Decompensated Chronic Liver Disease awaiting elective liver transplantation. 3. Post Liver Transplant patients with stable graft function.
Exclusion criteria
1. Negative consent. 2. Patients with ongoing medical and surgical issues (biliary complications, graft complication etc.). 3. Acute on Chronic Liver Failure and Acute Liver Failure patients.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Evaluation of sexual function by questionnaire method | pre transplant, 3,6,12 months | Arizona Sexual Experience Scale (ASEX) scores for sexual dysfunction, ASEX scores are 5 point questionnaire with scores given for each question from 1-6. Total scores More than or equal to 19 indicate sexual dysfunction (higher the scores greater the sexual dysfunction). |
| Evaluation of erectile dysfunction using questionnaire method | pre transplant, 3,6,12 months | International Index for Erectile Function - 5 (IIEF-5) scores for erectile dysfunction IIEF 5 scores are also a 5 point questionnaire with score ranging 0-6 for each question. Total scores less than 15 indicate mild to moderate erectile dusfunction and scores less than 11 indicate moderate erectile dysfunction (lower the scores higher the erectile dysfunction) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Correlation between testosterone and Meld Na scores | pre transplant, 3,6,12 months | Testosterone measured in ng/ml. Less than 2.84 ng/ml is considered as hypogonadism |
| Sarcopenia implication in recovery of sexual function. | pre transplant, 3,6,12 months | Sarcopenia measured by third lumbar vertebra Skeletal muscle index. Values less than 52 indicates sarcopenia |
Countries
India
Contacts
Primary ContactDr. Rajagopalan G, DNB
Outcome results
None listed