Postoperative Pain
Conditions
Brief summary
Little is known about comparative efficacy of gabapentin and diclofenac sodium in managing post-operative pain. Therefore, this study was planned to compare the efficacy of gabapentin, and diclofenac sodium for post-operative pain relief in patients undergoing major abdominal surgeries.
Detailed description
Non-steroidal anti-inflammatory drugs, opioid analgesics, and local and regional anesthesia have been used as preventive interventions, but their role in postoperative pain management remains inconclusive. Gabapentin is a relatively new drug for postoperative pain management whose side effects are well tolerated. If the findings of this study produce similar observations, it would add to the already scarce data and help patients undergoing major abdominal surgeries in the local settings in relieving postoperative pain effectively.
Interventions
DRUGGabapentin 600mg
Patients received a single oral dose of gabapentin 600 mg one hour before surgery.
DRUGDiclofenac Sodium 100 MG
Patients were given a single oral dose of diclofenac sodium 100 mg one hour before surgery.
Sponsors
Muhammad Aamir Latif
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
* Any gender * Aged 18-60 years * Undergoing elective major abdominal surgery under general anesthesia * With physical status I or II * Who were able to comprehend and use the Visual Analogue Scale (VAS) for pain assessment
Exclusion criteria
* With a known allergy or contraindication to gabapentin, or diclofenac sodium * A history of peptic ulcer disease * A history of gastrointestinal bleeding * Hepatic or renal dysfunction * Pregnancy or lactation * With neurological or psychiatric disorders affecting pain perception * Received opioids, anticonvulsants, antidepressants, or nonsteroidal anti-inflammatory drugs (NSAIDs) within 24 hours before surgery * With uncontrolled hypertension, ischemic heart disease, or diabetes mellitus * Those who experienced intraoperative complications necessitating a change in anesthetic plan or postoperative mechanical ventilation
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Pain reduction | 12 hours | Patients were considered to have effective pain relief (Yes) if their VAS score remained ≤3 throughout the monitoring period without requiring rescue analgesia. |
Countries
Pakistan
Outcome results
None listed