Carotid Doppler Screening for Subclinical Atherosclerosis in Diabetic CKD Patients.

Screening for Subclinical Atherosclerosis in Diabetic CKD Using Carotid Doppler

Status

Not yet recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT07266220

Acronym

DiCKD-CAROTID

Enrollment

Registered

2025-12-05

Start date

2026-01-31

Completion date

2027-04-30

Last updated

2025-12-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Atherosclerosis, Chronic Kidney Disease, Diabetes Mellitus, Type 2

Brief summary

This study is being done at Assiut University to look for early signs of hardening of the arteries (atherosclerosis) in people who have both diabetes and chronic kidney disease (CKD). Many patients with these conditions are at higher risk of heart disease and stroke, but the disease can develop quietly without symptoms. We will use a safe, non-invasive test called carotid Doppler ultrasound, which uses sound waves to check the neck arteries (carotid arteries) for early changes. The goal is to see how often these early changes occur in patients with diabetes and CKD, and whether the findings relate to their kidney function, blood sugar control, and other health factors. This research may help doctors detect vascular problems earlier and guide better prevention strategies for patients at risk.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

1. Age≥18years. 2. Diagnosis of type 2 diabetes mellitus (per treating physician or ADA criteria). 3. CKDstage3:eGFR30-59mL/min/1.73 m² on at least two measurements ≥3 months apart OR established diagnosis in medical record. 4. Clinically stable (no AKI, no hospitalization for cardiovascular event in past 3 months). 5. Ableandwilling to provide informed consent.

Design outcomes

Primary

Measure	Time frame	Description
Prevalence of subclinical carotid atherosclerosis (defined as increased carotid intima-media thickness and/or carotid plaque detected by carotid Doppler ultrasound).	At baseline (single assessment at enrollment).	Carotid Doppler ultrasound will be performed once at study entry to measure carotid intima-media thickness and detect the presence of carotid plaque. The percentage of patients with subclinical carotid atherosclerosis will be estimated among adults with type 2 diabetes mellitus and stage 3 chronic kidney disease.

Outcome results