Excess Base Comparison Between Pregnant Subjects With Severe Preeclampsia vs. Normotensive Pregnant Women

Comparison of Base Excess in Arterial Blood Gases Between Patients With Severe Preeclampsia and Normotensive Pregnant Patients

Status

Recruiting

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT07265336

Enrollment

100

Registered

2025-12-04

Start date

2025-08-15

Completion date

2026-01-31

Last updated

2025-12-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Preeclampsia, Severe Preeclampsia

Keywords

Excess base, Severe preeclampsia, Arterial blood gases

Brief summary

The study's primary goal is to compare the base excess (BE) values-an indicator of metabolic changes-in two groups of patients at Santo Tomás Hospital: those with severe preeclampsia and healthy, pregnant individuals. Researchers will measure these values using an arterial blood gas test before delivery or surgery. This is a prospective cohort study. The researchers will analyze various blood gas parameters, including pH, lactate, and BE, and then correlate the BE values with clinical variables and negative maternal outcomes. The expected outcome is that a abnormal BE values will be linked to a greater severity of preeclampsia. If this association is confirmed, BE could serve as an additional marker for predicting the severity of the condition and may lay the groundwork for future research on diagnostic and therapeutic standards based on blood gas analysis.

Interventions

DIAGNOSTIC_TESTArterial Blood gases

Determination of Excess Base in arterial blood gases before delivery / termination of pregnancy

Study design

Allocation

NON_RANDOMIZED

Intervention model

SINGLE_GROUP

Primary purpose

DIAGNOSTIC

Masking

NONE

Intervention model description

Both groups will have a blood sample taken for arterial blood gases. This test is not always indicated in severe preeclampsia and very rarely in normal patients. This is he reason we consider the study interventional.

Eligibility

Sex/Gender

FEMALE

Healthy volunteers

Yes

Inclusion criteria

* Gestational age: 24-40 weeks * Cases: Diagnosis of severe preeclampsia * Control: Normal blood pressure

Exclusion criteria

* Metabolic conditions that could hinder the results (diabetic ketoacidosis, sepsis, renal failure). * Clinical conditions that could hinder the results (diarrhea, vomit) * Recent use of bicarbonate

Design outcomes

Primary

Measure	Time frame	Description
Value of excess base	Immediately before delivery	Total measure of excess base measured by gasometry in an arterial blood sample
Hypertensive crisis	From admission to day three (3) after delivery	Elevation of the blood pressure above 160 (systolic) and 110 (diastolic).

Secondary

Measure	Time frame	Description
Lactate	Immediately before delivery	Concentration of lactate measured by gasometry in a sample of arterial blood.
Bicarbonate	Immediately before delivery	Concentration of bicarbonate measured by gasometry in arterial blood gases

Countries

Panama

Contacts

Primary ContactFrancisco Jordan, MD

fcojordan19@gmail.com+507 6983-0029

Backup ContactAdriana Martinz, MD

amartinzmd@gmail.com

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026