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Clip and Coil in Fundal Gastric Varices With a Large Shunt

Clip and Coil: A Novel Safe Strategy in Managing Fundal Gastric Varices With a Large Spontaneous Portosystemic Shunt

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT07263503
Enrollment
31
Registered
2025-12-04
Start date
2024-02-20
Completion date
2025-10-31
Last updated
2025-12-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Ectopic Embolization, Endoscopic Ultrasound (EUS)-Guided Coil Deployment, Fundal Gastric Varices, Gastric Variceal Pressure, Titanium Clips

Brief summary

Endoscopic ultrasound (EUS)-guided coil deployment is a promising technique for the endoscopic management of gastric varices. However, coil migration may occur in patients with large drainage collaterals. This study aimed to evaluate the safety and efficacy of using clips in combination with coils for treating gastric varices. In this retrospective study, clips were placed before EUS-guided coil deployment in each patient with gastric varices and a large spontaneous portosystemic shunt. The pressure of gastric varices was directly measured by puncturing the varix with a needle connected to a pressure transducer, before and after clip placement. The occurrence of ectopic embolization or coil migration was recorded.

Interventions

None listed

Sponsors

Second Affiliated Hospital, School of Medicine, Zhejiang University
Lead SponsorOTHER

Study design

Observational model
CASE_ONLY
Time perspective
RETROSPECTIVE

Eligibility

Sex/Gender
ALL
Healthy volunteers
No

Inclusion criteria

1. presence of a spontaneous portosystemic shunt, including gastrorenal or splenorenal collateral shunts; 2. use of both clips and coils during endoscopic intervention.

Exclusion criteria

The spontaneous portosystemic shunt was narrow (diameter \< 1.0 cm).

Design outcomes

Primary

MeasureTime frame
The occurrence of ectopic embolizationWithin the day of the endoscopic intervention (after the operation)

Secondary

MeasureTime frame
The occurrence of coil migrationWithin the day of the endoscopic intervention (after the operation)

Other

MeasureTime frame
Gastric variceal pressure gradientDuring the endoscopic intervention

Countries

China

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026