Preeclampsia, Pulmonary Edema - Acute
Conditions
Keywords
Pulmonary edema, Severe preeclampsia, B lines, Lung ultrasound
Brief summary
This research aims to evaluate the usefulness of lung ultrasound (LUS) for detecting and monitoring fluid overload in patients with severe preeclampsia. Severe preeclampsia is a leading cause of maternal death and illness worldwide, often causing fluid buildup that can lead to a serious complication called pulmonary edema, especially after delivery. The study will be a prospective, longitudinal observational study with a diagnostic validation component. It will involve patients with a diagnosis of severe preeclampsia who meet specific inclusion criteria. Each participant will undergo a clinical exam and a lung ultrasound, which will assess eight zones of the lungs. The total number of B-lines-a sign of interstitial edema-will be documented. Data will be collected at three key times: upon admission, in the immediate postpartum period (within 24 hours of delivery), and 7-10 days postpartum. The results from the LUS will be compared to clinical signs like shortness of breath, rapid breathing, crackling sounds in the lungs, and oxygen saturation levels. The expected impact of this research is to provide evidence that LUS is a valuable, non-invasive, and accessible tool for the early detection of pulmonary congestion in patients with severe preeclampsia. This could lead to improved clinical decision-making and a reduction in maternal respiratory complications.
Interventions
DIAGNOSTIC_TESTLung ultrasound
Lung ultrasounf at three moments (at admission, before delivery and immediate post partum) to determine B Lines
Sponsors
Saint Thomas Hospital, Panama
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Healthy volunteers
No
Inclusion criteria
* Preeclampsia with severe features. * Gestational age 24 weeks - 41 weeks.
Exclusion criteria
* Chronic lung disease. * Known heart disease. * Diagnosis of lung edema at admission * Body mass index \> 40 * Need for immediate delivery
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Lung Ultrasound evaluation | One evaluation at admission, another one just before delivery and a final one 24 hours after delivery | Three or more B Lines in at least two lung zones using lung ultrasound |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Dyspnea | Report of the symptom by the patient from admission for up to three days | Subjective sensation of difficulty breathing |
| Tachypnea | Report of the symptom from admission for up to three days. | Respiratory rate above 20 breaths/min |
| Oxygen saturation | Report of the value measured by a pulse oxymeter from admission for up to three days | Oxygen saturation measured by pulse oxymeter |
Countries
Panama
Contacts
Primary ContactAnna C Figueroa, MD
Backup ContactAdriana Martinz, MD
Outcome results
None listed