Intrabony Defect, Intrabony Defects in Chronic Periodontitis
Conditions
Keywords
I-PRF with xenograft
Brief summary
Evaluate of the injectable platelet rich fibrin (I-PRF) with xenograft in Intrabony defects of Periodontitis patient stage III versus Xenograft alone.
Detailed description
All surgical procedures will be conducted by a single operator. Following administration of local anesthesia, intrasulcular incisions will beperformed buccally and lingually/palatally on the affected tooth and extended one adjacent tooth mesially and distally, using 15c blades. Following mucoperiosteal flap elevation, thorough debridement will be performed using ultrasonic scalers and curettes until defects are clear from any granulation tissue, and the defect morphology will be visually explored and recorded. In the group1: xenograft alone(Bovin xenograft)will be applied to the intrabony defect area. In the group 2: xenograft (Bovin xenograft) with injectable platelet Rich fibrin (I- PRF) will be applied to the intrabony defect area. Preperation of Injectable platelate Rich Fibrin (I-PRF) : will be prepared for each patient as follows: 5 ml of venous blood will be collected from the patient blood then placed in a plastic tube without any added material or coagulant and centrifuged at 700 rpm for 3 min. then mixed with Xenograft. Finally, the flap will be passively repositioned using interrupted 4-0 silk
Interventions
PROCEDUREinjectable platelet rich fibrin and xenograft
Elevation of papilla preservation flap at the site of 3mm infrabony defect ,prepearing the I-PRF which is obtained from the patients own blood , centrifuged at 700 rpm in 3 min and mixed with xenograft than placed at the defect area after removal all the granulation tissue follow up after 3 and 6 months intervals
PROCEDUREXenograft alone
Elevation of papilla preservation flap at the site of 3mm infrabony defect after removal all the granulation tissue, the xenograft alone inserted to the defect, suturing and follow up after 3 and 6 months intervals
Sponsors
Al-Azhar University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
30 Years to 55 Years
Healthy volunteers
Yes
Inclusion criteria
1. Patient should have localized Periodontitis stage III grade B with pocket depth ≥ 6mm; indicated for periodontal surgery 2. Patient's agreement to the surgical procedure and clinical trial. 3. Age ranged between 30-55 years old. 4. Intrabony defects with depth ≥3mm. 5. Free from any systemic conditions and no previous drug affect bone metabolism
Exclusion criteria
1. Smoking. 2. Pregnant women. 3. Patients in variation in anatomical landmarks. 4. Patients with psychological problems. 5. Patients with abnormal habits.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Radiographic parameters | 6 months after treatment | • The bone fill after 6 months postoperatively using digital periapical radiography using parallel technique. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Pocket depth (PD) | presurgically, 3 and 6 months interval after treatment | will be assessed by William graduated periodontal Probe in 4 surfaces of the tooth |
| Plaque index (PI) | pre-surgically 3 months and 6 months respectively | According to Silness & Loe, 4 readings will be recorded for each surface of the teeth (buccal, lingual, mesial and distal) and it is given a score from 0-3 |
| Gingival index (GI) | pre-surgically 3 months and 6 months respectively | presence or absence of bleeding on upon gentle probing |
| Clinical attachment level (CAL) | pre-surgically 3 months and 6 months respectively | will be measured from the cement-enamel junction to the base of the pocket |
Countries
Egypt
Outcome results
None listed