Induction of Labor, Labor (Obstetrics)--Complications, Prelabor Rupture of Membranes
Conditions
Keywords
prelabor rupture of membranes, complicated labor, early Versus delayed labor induction
Brief summary
To compare the effects of early V/s delayed induction of labour and its outcomes in patients presenting with PROM without labour.
Detailed description
This is a comparative study where the patient who presented with PROM were assigned 2 groups of intervention . One had early induction of labour and other had induction of labour after 24 hours of observation. Both groups were compared for the average time of labour till delivery of the fetus and the frequency of spontaneous vaginal delivery was also calculated for each group.
Interventions
DRUG0.5mg PGE2 gel
In this interventional group patients presenting with PROM will be immediately induced by 0.5mg PGE2 gel. If bishop score will not improve after 6 hours, then application of PGE2 gel will be repeated (maximum 2 doses)
Sponsors
Laiba Qamar
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Healthy volunteers
No
Inclusion criteria
1. singleton pregnancy with cephalic presentation 2. gestational age between 37-41 weeks as calculated by last menstrual period date or early dating ultrasoumd 3. Spontaeous PROM as confirmed by history and sterile speculum examination 4. modified bishop score \<6 5. no detectable uterine contractions on admission 6. clear liqour and duration of PROM \<6 hours at admission
Exclusion criteria
1. meconium stained liqour 2. patients with features of chorioamnionitis (fever , tachycardia, abdominal tendernessor foul smeeling vaginal discharge 3. maternal medical diseaseincluding prompt delivery or C section like severe preeeclampsia, renal or cardiac disease 4. presence of contraindications to labour such as placenta previa , Vasa previa,previous uterine surgery (e.g myomectomy ) that increases the risk of uterine rupture , previous C section 5. history of antepartum hemorrhage 6. Moderate to severe IUGR as diagnosed on ultrasound and doppler studies
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Duration of labour | 24 hours | the duration of labour was assesed after each method of induction when patients presented with PROM |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Frequency of Normal Vaginal Delivery | 24 hours | Frequency of having a vaginal delivery was calculated in each interventional group |
Countries
Pakistan
Outcome results
None listed