Prognostic Impact of Frailty in Cardiogenic Shock

Prognostic Impact of Frailty in Cardiogenic Shock: Nationwide Cohort Study

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT07260084

Enrollment

207419

Registered

2025-12-03

Start date

2012-01-01

Completion date

2023-10-31

Last updated

2025-12-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Age, Cardiogenic Shock, Frailty

Keywords

frailty, cardiogenic shock, Hospital Frailty Risk Score, Age

Brief summary

The goal of this observational study is to show prognostic impact of frailty in cardiogenic shock according to age. The main questions it aims to answer are: * Can frailty successfully predict outcomes in cardiogenic shock? * Whether the impact of frailty would differ with age in cardiogenic shock?

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Adults aged ≥18 years who were admitted to the intensive care unit (ICU) of tertiary hospitals and were diagnosed with CS

Exclusion criteria

* Patients diagnosed with anaphylaxis * Patients with a documented history of shock in the year before the index admission

Design outcomes

Primary

Measure	Time frame	Description
In-hospital all-cause mortality	During index hospitalization for cardiogenic shock (up to hospital discharge)	Death from any cause occurring during the index hospitalization for cardiogenic shock. Number of participants with the event was measured

Secondary

Measure	Time frame	Description
Heart failure-related rehospitalization	From index hospitalization until 15 years of follow-up.	Any inpatient admission with a primary or secondary diagnosis of heart failure (ICD-10 I50.x), identified from claims data and prescription records.Number of participants with the event was measured.
Cognitive impairment	From index hospitalization until 15 years of follow-up.	New-onset cognitive dysfunction after discharge, defined using ICD-10 codes (R41.x for memory disturbance, F06.7 for mild cognitive disorder) or new diagnosis of dementia (F00-F03, G30) or prescription of anti-dementia medications (donepezil, rivastigmine, galantamine, memantine). Number of participants with event was measured
Mental health problems	From index hospitalization until 15 years of follow-up.	Composite of new-onset psychiatric diagnoses after discharge including 6 domains defined using ICD-10 codes. Domains include depression (ICD-10 F32-F33), anxiety disorders (F41.x), somatization disorder (F45.x), stress-related disorders (F43.x), sleep disorders (G47.x), and substance use disorders (F10-F19). Diagnostic codes supported by prescription data (e.g., antidepressants, anxiolytics). Number of participants with the event was measured.
Long-term all-cause mortality	From index hospitalization until 15 years of follow-up.	Death from any cause, identified with the Statistics Korea nationwide death registry. Number of participants with the event was measured.

Outcome results