Clinico-Epidemiological Profile Of Acquired Aplastic Anemia Among Children At Assiut Governorate .

Acquired Aplastic Anaemia

1. Assessment the clinical presentation and epidemiological profile of children with acquired aplastic anemia. 2. Determining the possible risk factors and associated conditions contributing to the development of acquired aplastic anemia.

Aplastic anaemia is a term describing the common findings of pancytopenia and marrow hypoplasia from arising variety of disease states, including acquired aplastic anaemia and a variety of congenital marrow failure states(1). The global incidence of paediatric AA varies geographically, with rates of 2 to 3 cases per million per year in Europe, but higher in East Asia and certain developing regions(2) .Among Egyptian Children, inherited bone marrow failure syndromes (BMFS), including AA, constitute about 10-15%of all BMFS and up to 30% of paediatric BMFS ,with an average of 65 cases per million live births each year .Acquired AA remains the predominant from in older children and adolescent , while inherited forms are more common in younger children(3).The clinical presentation of aplastic anaemia regularly consists of symptoms associated with pancytopenia, including fatigue, pallor, bruising, bleeding, and extended susceptibility to infections(4). Identified etiologic risk factors include infections of viral origin, such as hepatitis-associated, Epstein-Barr, parvovirus, human immunodeficiency virus, varicella zoster, measles and other viruses, as well as exposure to toxic chemicals (e.g. benzene, pesticides and insecticides) and ionizing radiation (5). Over the last three decades, bone marrow transplantation (BMT) from a matched related donor (MRD) has been the treatment of choice for children with acquired AA (6) The Rationale of our study: aplastic anaemia in children is a serious ,life threatening bone marrow failure syndrome ,often resulting from immune-mediated destruction of hematopoietic stem cell triggered by factors such as viral infections, environmental toxin, or genetic predispositions and requires precise diagnosis to distinguish from inherited bone marrow failure syndromes or hypoplastic myelodysplastic syndrome to guide appropriate treatment strategies . The Research question: What is the clinico-epidemiological profile of acquired aplastic anaemia among children at Assiut governorate.

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