Inflammatory Bowel Diseases
Conditions
Brief summary
Crohn's disease (CD) and ulcerative colitis (UC) are two major types of inflammatory bowel disease (IBD) that are identified by different clinical, endoscopic, pathological, and radiologic diagnostic methods. In the past few years, the incidence of inflammatory bowel disease has been increasing worldwide, with the incidence of UC being higher than that of CD. Vitamin D is a fat-soluble vitamin that is produced in the skin by a UV-dependent reactionand then hydroxylated by the kidneys and liver, and is converted to its active form, 1,25-dihydroxyvitamin D. Vitamin D deficiency is common throughout the world and its deficiency rates ranging from 30 to 50% have been reported. Several studies have shown the role of vitamin D as a regulator of the immune system and its inhibitory function incellular immunity and production of pro-inflammatory cytokines that play a major role in autoimmune diseases. In some human studies, the link between vitamin D levels and the disease severity of IBD has been shown, but it is not clear whether lack of vitamin D is the cause or consequence. In this study, we aimed to investigate the relationship between inflammatory bowel disease and itsflare-up with serum levels of vitamin D
Interventions
DIAGNOSTIC_TESTSerum 25(OH)D (Vitamin D3), C- reactive protein, Erthrocyte sedimentation rate
Serum 25(OH)D (Vitamin D3), C- reactive protein, Erthrocyte sedimentation rate are evaluated to assess vitamin D deficiency and IBD activity
Sponsors
Assiut University
Study design
Observational model
OTHER
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Adults aged ≥18 years * Diagnosed with crohn's and ulcerative colitis * Regular follow-up in IBD clinic * Recent vitamin D and disease activity assessment (within 1 month)
Exclusion criteria
* Current vitamin D supplementation(\>1000IU/day) * History of malabsorption syndromes (e.g.,celiac disease) * Chronic kidney or liver disease * Pregnancy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Prevalence of vitamin D deficiency in patients with active inflammatory bowel disease | Recent vitamin D and disease activity assessment (within 1 month) | This will be done by measuring the vitamin D level in the serum of patients with active inflammatory bowel diseases (in nanograms/ milliliter) |
Contacts
Primary ContactNoor el-Deen A. Mohamed, Professor of internal medicine
Backup ContactAhmed A. Maghraby, Lecturer of internal medicine
Outcome results
None listed