Hemophilia
Conditions
Brief summary
In the course of a cross-over study design, 12 patients with hemophilic arthropathy will perform a training load on the knee extensor muscles. The subjects will each perform one intervention with blood flow restriction and one with a Sham-BFR intervention.
Interventions
DEVICEControl
Sham-BFR Exercise (20mmHg) while Leg Press Exercise (4 Sets, All out)
DEVICEBFR Exercise (50% of the LOP) while Leg Press Exercise (4 Sets, All out)
BFR Exercise (50% of the LOP) while Leg Press Exercise (4 Sets, All out)
Sponsors
University Hospital, Bonn
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* patients with haemophilia * Ability for an exercise intervention
Exclusion criteria
* Sickle Cell Anemia * Intravascular stents/bypasses * Open Wounds/Infections of the lower extremity
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Pain threshold | Pre- (Baseline, before Exercise) to immediately Post-Intervention (after the exercise training intervention) and 24 hours after intervention | Pain threshold measurement (PTT): The test determines the amount of pressure (in kg) over a given area in which a steadily increasing nonpainful pressure stimulus turns into a painful pressure sensation. |
| Quality of Life Score | Pre- (Baseline, before Exercise) to immediately Post-Intervention (after the exercise training intervention) and 24 hours after intervention | Hemophilia Joint Health Score |
Countries
Germany
Outcome results
None listed