Subglottic Stenosis, Tracheal Stenosis
Conditions
Brief summary
Benign tracheal stenosis is a rare but potentially life-threatening condition, typically resulting from fibroinflammatory scarring. It can be secondary to iatrogenic etiologies such as intubation or tracheostomy , as well as autoimmune diseases and being idiopathic. Patients typically undergoes endoscopic or surgical interventions to open up the airways. This project will analyze resected or biopsied tissue from patients with benign tracheal stenosis to define disease-specific RNA expression profiles.
Interventions
PROCEDUREBiopsy or surgery
The tissue will be obtained from biopsy or surgical resection. All the intervention will be performed for clinical needs. The tissue used in the study will be considered as discarded tissue
Sponsors
University of Maryland, Baltimore
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Patients with benign tracheal stenosis
Exclusion criteria
* Malignancy. active infection
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| RNA profile | 1 year | The diseased mucosa will show a increased fibrosis and inflammation profile compared with that from normal mucosa |
Countries
United States
Contacts
Primary ContactChenchen Zhang, MD
Outcome results
None listed