Idiopathic Parkinsonism
Conditions
Keywords
Parkinson's disease, Fall risk, Motor fluctuation, Dopaminergic medication, Mobile health, Sit-to-Stand, Kinetikos Health App
Brief summary
This is a single-center, prospective observational study aiming to validate the Kinetikos Health App for fall risk assessment in PD patients undergoing dopaminergic medication adjustments.
Detailed description
Falls are common and disabling in PD. Dopaminergic medication effects on fall risk remain inconclusive. This study validates the Kinetikos Health App for objective fall risk assessment before and after medication adjustment.
Interventions
OTHERNo Intervention: Observational Cohort
No intervention.
Sponsors
Taipei Medical University Shuang Ho Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
20 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. Age ≥20; 2. PD diagnosis (MDS criteria); 3. On levodopa monotherapy with motor fluctuations; 4. Planned to start opicapone or safinamide; 5. Consent provided.
Exclusion criteria
1. Atypical/secondary parkinsonism; 2. Moderate-severe dementia; 3. DBS/MRgFUS/neurosurgery within 6 months; 4. Severe comorbidities limiting test
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in fall-risk index (Kinetikos Health App Sit-to-Stand) | From baseline to 3 months |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| UPDRS | From baseline to 3 months | Change in MDS-UPDRS axial score; Change in MDS-UPDRS Part II |
| Fall events | From baseline to 3 months | Fall events during 3 months |
| LEDD | From baseline to 3 months | Change in LEDD |
Countries
Taiwan
Contacts
Primary ContactChen-Chih Chung, MD
Backup ContactChien Tai Hong, MD, PhD
Outcome results
None listed