Tooth Extraction Site Healing, Wound Healing
Conditions
Keywords
lower third molars, socket healing, i-PRF
Brief summary
The aim of this study is to compare extraction socket healing (SH) following surgical extraction of lower third molars (LTMs) with and without the application of injectable platelet rich fibrine (i-PRF). A minimum of 32 participants will be included. One mandibular third molar per participant will be randomly assigned to the control group and the contralateral tooth to the test group. SH, gingival recession, and distal periodontal pocket depth of the adjacent second molar will be assessed, and outcomes compared between sides.
Detailed description
Surgical extraction of lower third molars (LTMs) is the most commonly performed procedure in oral and maxillofacial surgery (OMFS). Healing of the extraction socket is a key outcome in oral surgery, as complications in healing may lead to delayed recovery, persistent pain, infection, and adverse events such as dry socket. The aim of this study is to compare extraction socket healing (SH) following surgical extraction of LTMs with and without the application of injectable platelet rich fibrine (i-PRF). For this purpose minimum 32 participants from both sexes will be included to the study. For each participant, one LTM (right or left) will be randomly assigned to the control group and the contralateral tooth to the test group. In the control group, the extraction socket will be irrigated with 0.9% physiological saline solution following standard extraction, whereas in the test group, the socket will be irrigated with i-PRF. SH will be assessed on postoperative days 3 and 14, and at 6 weeks, using the Inflammatory Proliferative Remodeling (IPR) scale and the hydrogen peroxide (H₂O₂) test. Gingival recession and the depth of the periodontal pocket at the distal aspect of the adjacent second molar will be recorded on postoperative days 7 and 14. The outcomes will be compared between the two sides with respect to wound healing.
Interventions
PROCEDURESurgical extraction of lower third molars.
Surgical extraction of lower third molars: Impacted or difficult-to-remove lower wisdom teeth are removed using surgical techniques, involving an incision in the soft tissue and removal of bone.
Sponsors
Saglik Bilimleri Universitesi
Study design
Allocation
RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
SUPPORTIVE_CARE
Masking
SINGLE (Outcomes Assessor)
Masking description
The investigators who performed clinical measurements were not involved in the operation and were blinded as to which treatment group the tooth was assigned.
Intervention model description
To reduce inter-individual variability and minimize bias in estimating the treatment effect, the study was designed as a split-mouth trial, with the two treatments randomly assigned to either the right or left side of the dentition.
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
Individuals of both sexes Age over 18 years Non-smokers Systemically healthy (ASA I) Requiring surgical extraction of bilateral mandibular third molars
Exclusion criteria
Lack of consent to participate Pregnancy Smokers
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Evaluation of socket healing | 6 weeks | Socket healing of the extracted tooth will be evaluated by using IPR scale which allows to evaluate the healing process according to its biological phases. |
Countries
Turkey (Türkiye)
Outcome results
None listed