Critical Illness
Conditions
Brief summary
Critically ill patients, such as those with trauma or sepsis, experience high rates of malnutrition (up to 75%). Malnutrition worsens outcomes by increasing infection rates, hospital stays, mortality, and healthcare costs. Adequate nutrition is therefore crucial in the ICU. To ensure appropriate nutrition, accurate determination of total energy expenditure (TEE) is essential. In practice, predictive equations are often used, but these can misestimate TEE in ICU patients due to complex metabolic changes. Indirect calorimetry is recommended but limited by technical constraints. Consequently, the doubly labeled water (DLW) method, though expensive, offers a precise and non-invasive way to measure TEE over time. This study applies the DLW method in ICU patients to improve energy assessment and guide personalized nutrition strategies that support recovery and outcomes.
Interventions
DIAGNOSTIC_TESTDLW-based energy assessment
Measuring TEE in IC patients with DLW
Sponsors
Maastricht University Medical Center
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
SUPPORTIVE_CARE
Masking
NONE
Intervention model description
The study is a prospective, interventional trial with a single group design.
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Admitted to the ICU of Jessa Hospital * Male and female sexes * Age: \> 18 years old * Expected ICU stay of 5 days or more
Exclusion criteria
* Dialysis
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Energy expenditure | Min: 1-5 days; Max: 1-20 days | Measured using the DLW method by only taking urine samples |
Countries
Belgium
Contacts
Primary ContactMichèlle Hendriks
Outcome results
None listed