Biopsy, Fine-Needle/Methods, Lung Cancer (Diagnosis)
Conditions
Keywords
NSCLC, Non-small cell lung cancer, Transthoracal needle aspiration, Biopsy, Diagnostics
Brief summary
* The objective of this research is to determine the accuracy of different types of lung transthoracal needle aspiration (TTNA) i.e. jabbing-then-suction, suction-with-jabbing, and suction-only TTNA in patients with suspected lung cancer. * Researchers will compare these techniques to determine whether there are any quality differences in the obtained tumor samples
Detailed description
During hospitalization for diagnostic testing, suspected lung cancer patients will undergo a transthoracic biopsy using three TTNA techniques, and core needle biopsy as the gold standard. The biopsy is performed in the operating room under local anesthesia and under the supervision of an anesthesiologist. The biopsy techniques used are routine procedures and therefore not as a new method. After the biopsy is completed, the patient is observed for at least 24 hours to observe potential complications.
Interventions
DIAGNOSTIC_TESTJabbing-then-Suction, Suction-with-Jabbing, and Suction-only Transthoracal Needle Aspiration (TTNA) Techniques
Each of patient will undergo three types of different transthoracal needle aspiration (TTNA)
Sponsors
Gadjah Mada University
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Masking description
The biopsy results, in a form of 20 cc syringe and slide containing the patient's tissue sample, will be labeled with a code by pulmonologist that will be blinded to the pathologist. The pathologist will then assess the adequacy of the cell count for molecular examination, evaluate the histopathological and cytopathological findings. Statisticians who will process the data are unaware of the allocation of each research item.
Intervention model description
All patient undergo the same intervention
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients with suspected lung cancer who will undergo diagnostic testing using ultrasound-guided TTNA of the lung with cell block and core biopsy. * Patients aged 18-75 years. * The tumor is located peripherally, attached to the chest wall.
Exclusion criteria
* Patient refuses lung biopsy * Non-cooperative patient * Patient with respiratory failure, on positive pressure ventilation * Severe pulmonary emphysema * Contralateral pneumonectomy * Advanced pulmonary fibrosis * Platelet count \<100,000/mm3 and international normalized ratio (INR) \>1.4
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Quality of samples from different types of transthoracal needle aspiration (TTNA) technique | Immediate after biopsy procedure | To determine the quality of samples between the jabbing-then-suction technique, the suction-with-jabbing technique, and the suction-only technique of transthoracic needle aspiration procedures in patients with unsuspected lung cancer. The sample quality assessed includes the adequacy of the number of tumor cells for molecular examination and the concordance between cytology sample of each type of TTNA technique. |
Countries
Indonesia
Contacts
Primary Contactdr. Roihan Mohamad Iqbal
Outcome results
None listed