Cognitive Dysfunction, Memory Disorders
Conditions
Brief summary
The purpose of this study is to test the use of a screening tool to detect changes in the eye that are associated with Alzheimer's disease in adult participants with memory issues. For each participant, the study will last up to one month and requires one visit to the research site.
Interventions
OTHERRetinal scan
Detailed image of the retina.
OTHERBlood test
Sample will be used to test for a specific form of a protein in the blood to learn more about early detection of Alzheimer's disease.
Sponsors
Eli Lilly and Company
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
55 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Participants who are overtly healthy as determined by medical evaluation, including medical history and physical examination. * Have mild memory complaints or a diagnosis of mild cognitive impairment. * Have undergone genotyping for apolipoprotein E (APOE) and are willing to make results available to the investigator. * Montreal Cognitive Assessment (MoCA) score of greater than or equal to 22 and less than or equal to 28.
Exclusion criteria
* Have any medical condition that, in the opinion of the investigator, would be a contraindication to participation in the study. * Have an existing diagnosis of AD or other dementia. * Have contradictions to or an allergy to the ophthalmic dilating agents. * Have known diagnosis of severe glaucoma or severe cataracts; have a significant refractive error (more than 12 diopters \[D\] of spherical equivalent refraction); or have any ocular media opacity that prevents imaging of the retina (that is, severe cataract). Note: mild to moderate cataracts or vision correction with glasses or contact lenses are not
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Percentage of Participants with the Same Results on the Blood Test and Retinal Scan | Day 1 |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Percentage of Participants who Report High or Moderate Satisfaction with Retinal Scan | Day 1 | Measured by 5-item retinal scan feedback survey. Participants rate their experience with the retinal scan on a 5-item Likert scale that ranges from Strongly Disagree to Strongly Agree. Higher scores are better. |
Countries
United Arab Emirates
Contacts
Primary ContactTrial questions or participation questions: 1-877-CTLILLY (1-877-285-4559) or
Backup ContactPhysicians interested in becoming principal investigators please contact
Outcome results
None listed