Hyperandrogenism
Conditions
Keywords
fertility
Brief summary
Hyperandrogenism is a common reason for consultation, the causes of which can range from common conditions (PCOS) to rarer conditions with major genetic implications (NC21OHD). It is characterized by elevated levels of circulating androgens, mainly testosterone. This excess of androgens usually manifests clinically as increased male-pattern hair growth and, less specifically, acne and alopecia. Its prevalence is estimated at between 6 and 12% in women of reproductive age, and its incidence is increasing. It is also responsible for infertility. As a reminder, infertility is a major public health issue and affects more and more couples around the world. The investigators therefore wish to develop innovative tools to improve the diagnosis and management of hyperandrogenism
Detailed description
Hyperandrogenism is a common reason for consultation, the causes of which can range from common conditions (PCOS) to rarer conditions with major genetic implications (NC21OHD). It is characterized by elevated levels of circulating androgens, mainly testosterone. This excess of androgens usually manifests clinically as increased male-pattern hair growth and, less specifically, acne and alopecia. Its prevalence is estimated at between 6 and 12% in women of reproductive age, and its incidence is increasing. It is also responsible for infertility. As a reminder, infertility is a major public health issue and affects more and more couples around the world. The investigators therefore wish to develop innovative tools to improve the diagnosis and management of hyperandrogenism
Interventions
OTHERdata collection
collection of data from medical records over a period of 5 years
Sponsors
Assistance Publique - Hôpitaux de Paris
Study design
Observational model
COHORT
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
FEMALE
Age
16 Years to 45 Years
Healthy volunteers
No
Inclusion criteria
* Patients of childbearing age (16 to 45 years old) * Suffering from hyperandrogenism * Established etiological diagnosis with elimination of differential diagnoses * Informed and not opposed to the collection of their data for the purposes of the study
Exclusion criteria
* Pregnancy * Patients under legal protection measures
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Use of machine learning models combined with metabolomics to distinguish between different causes of hyperandrogenism | 5 years |
Secondary
| Measure | Time frame |
|---|---|
| Use of metabolomics to improve the management of patients with hyperandrogenism | 5 years |
| Use of metabolomics to predict CYP21A2 genotyping results | 5 years |
| Study of the impact of anti-androgenic hormone therapy on the predictive capabilities of the model | 5 years |
Contacts
Primary ContactAnne Pr BACHELOT
Outcome results
None listed