The Effect of Gender-affirmative Measures on Breast Perception in Trans Men

The Effect of Gender-affirmative Measures on Breast Perception in Trans Men (TRANSBREAST) - a Prospective Cohort Study

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT07252687

Acronym

TRANSBREAST

Enrollment

100

Registered

2025-11-28

Start date

2025-11-30

Completion date

2030-11-01

Last updated

2026-03-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Gender Dysphoria in Adolescents and Adults, Transgender

Keywords

transgender, breastdysphoria, trans male, non binary, genderdiverse

Brief summary

Breast dysphoria in transmasculine or genderdiverse individuals is a distinct psychological burden associated with depression, anxiety and suicidality. The aim is to systematically investigate the effect of GAHT (gender-affirming hormone therapy) and mastectomy on this form of dysphoria. The primary objective of this study is to analyse and investigate the psychological and physical effects of breast development on trans men or genderdiverse individuals. A secondary objective is to determine the extent to which the stress affects the well-being of trans men depending on the coping strategies used (binding vs. taping).

Interventions

OTHERquality of life questionnaire- iTransQoL, chest dysphoria measure

Before starting treatment, participants should complete the Chest Dysphoria Measure and iTransQoL questionnaires (=time point 0). The second time point for completing the questionnaires again is 3 months after starting hormone therapy. Subsequently, the questionnaires should be completed a third time after breast-affirming surgery. The final survey takes place two years after time point 0, or 6 months after the previous survey.

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

FEMALE

Age

16 Years to No maximum

Inclusion criteria

* AFAB (Assigned Female At Birth) * before starting GAHT * before mastectomy

Exclusion criteria

* Ongoing GAHT * Mastectomy already performed * Lack of capacity to give consent * Insufficient knowledge of German

Design outcomes

Primary

Measure	Time frame	Description
Chest Dysphoria Measure Score	From enrollment to the end of observation after 2 years	Chest Dysphoria Measure Score before GAHT, during GAHT, and after mastectomy. Possible chest dysphoria scores range from 0 to 51, with higher scores indicating greater distress.

Countries

Austria

Contacts

CONTACTKatharina Feil

katharina.feil@i-med.ac.at+4351250423276

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 7, 2026