Periapical Periodontitis
Conditions
Brief summary
This randomized controlled trial aims to compare the effectiveness of calcium hydroxide mixed with 0.2% chlorhexidine digluconate versus calcium hydroxide mixed with saline as intracanal medicaments in reducing postoperative pain in patients with apical periodontitis. A total of 80 adult patients with anterior teeth diagnosed with apical periodontitis will be randomly assigned to two equal groups. After standard chemomechanical root canal preparation, Group A will receive calcium hydroxide with saline, while Group B will receive calcium hydroxide with 0.2% chlorhexidine. Postoperative pain will be assessed using a 10-point Visual Analogue Scale (VAS) at 12, 24, and 48 hours. The primary outcome is the frequency and severity of pain at 24 hours. Data will be analyzed using chi-square or Fisher's exact test, with a significance level of p \< 0.05. The study aims to determine whether the addition of chlorhexidine improves the analgesic and antimicrobial effectiveness of calcium hydroxide during root canal treatment.
Interventions
DRUGCalcium Hydroxide + Normal Saline
Calcium hydroxide powder mixed with sterile normal saline and placed inside the root canal as intracanal medicament.
DRUGCalcium Hydroxide + 0.2% Chlorhexidine Digluconate
Calcium hydroxide powder combined with 0.2% chlorhexidine solution and placed inside the root canal as intracanal medicament.
Sponsors
Aqsa Afzal
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* • Patients age 18 or above 18 year old (to have complete apex formation) * Anterior teeth with apical periodontitis (simple root canal morphology) * Patients whose medical history does not include a history of certain illnesses, such as HIV, heart disease, or epilepsy (conditions that can affect a patient's rate of healing).
Exclusion criteria
* Patient allergic to chlorhexidine digluconate and Calcium hydroxide assessed by history. * Tooth having necrotic pulp on radiographic examination and electric pulp tester. * Multiple rooted teeth. * Previously root canal treated tooth because of procedural errors and periapical infection.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| primary outcome measure | 24 hours after placement of intracanal medicament (pain also recorded at 12 and 48 hours, but final outcome measured at 24 hours). | Postoperative pain will be assessed using a 10-point Visual Analogue Scale (VAS), where 0 = no pain, 1-3 = mild pain, 4-6 = moderate pain, and 7-10 = severe pain. |
Countries
Pakistan
Outcome results
None listed