Class I Obesity, Overweight , Obesity
Conditions
Keywords
Healthy Weight, Stage I Hypertension
Brief summary
The purpose of this research is to test how processing food can affect how one's body responds to it.
Detailed description
The purpose of this project is to address the current gap in research on ultra-processed foods (UPFs) and cardiometabolic health with a feeding study that addresses the limitations of previously conducted intervention studies in matching UPF- and unprocessed- foods intervention diets for diet quality, nutrient content, and food type. Therefore, the primary objective is to evaluate diets composed primarily of ultra-processed or less processed foods that meet dietary guidelines recommendations on chronic disease risk factors. More specifically, when Dietary Guidelines for Americans (DGA)-compliant diets comprised of mostly ultra-processed and unprocessed foods (per Nova) are fed to generally healthy participants, determine whether there is an impact on: * blood pressure * fasting glucose and insulin concentrations, or * lipid panel (total cholesterol, HDL-C, LDL-C, triglycerides).
Interventions
OTHERLow-processed DGA Diet
Participants will consume a DGA menu made up of low-processed foods over a 4-week period
OTHERUltra-processed DGA Diet
Participants will consume a DGA menu primarily made up of ultra-processed foods over a 4-week period
Sponsors
USDA Grand Forks Human Nutrition Research Center
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
OTHER
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* BMI 18.5-34.9 kg/m2 * Systolic \<139 mm Hg and Diastolic \<90 mm Hg * Able to understand and sign the consent form * Have own transportation to the Grand Forks Human Nutrition Research Center * Not allergic to study foods or unwilling to eat them * Willing to comply with study demands * Able to read and understand English
Exclusion criteria
* Taking statins or medication to lower blood pressure, * Taking anti-inflammatory or anti-diabetes medications * Pregnant, lactating, or planning to become pregnant * Diagnosed with an eating disorder * Taking weight loss medications * Smoke or use other tobacco products, including e-cigarettes * Have overt hypothyroidism * Diagnosed with cancer * Exercise more than 30 minutes per day 2 or more days per week * Allergic to study foods * Express unwillingness to consume study foods at the screening appointment
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Mean difference in systolic and diastolic blood pressure from baseline | Week 0, Week 4 | Mean difference in systolic and diastolic blood pressure from baseline |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Mean difference in fasting glucose and fasting insulin concentrations from baseline | Week 0, Week 4 | Mean difference in fasting glucose and fasting insulin concentrations from baseline |
| Mean difference in fasting triglyceride concentrations from baseline | Week 0, Week 4 | Mean difference in fasting triglyceride concentrations from baseline |
Countries
United States
Contacts
PRINCIPAL_INVESTIGATORJulie Hess, PhD
USDA Grand Forks Human Nutrition Research Center
Outcome results
None listed