Donor and Recipient Mismatch in Liver Transplantation

Graft Survival, Liver Disease (Alcoholic or Not), Liver Transplant Surgery, Patient Survival

liver transplantation, patient survival, gender mismatch, long-term outcome, organ allocation

This observational study aims to investigate the impact of gender disparity between donors and recipients on long-term outcomes after liver transplantation (LT). The study aims to answer the following question: Does gender mismatch lower the possibility of survival after liver transplantation? Participants demonstrate gender dicrepancies between donors and recipients as regular concept in LT. The retrospective cohort study investigates the impact over a long-term follow up of 10 years.

The study involves patients who undergo liver transplantation at the Ajmera Transplant Centre Toronto from 2014 until 2022. The observation period ended at the first January 2025 to provide a minimal follow up of 24 months. Liver transplant recipients with gender mismatch (A) will be compared with liver transplant recipients without gender mismatch (B). Liver transplantation is the only curative treatment for people with end stage liver disease. Gender mismatch between donor and recipient, particularly, the combination of a female donor to male recipient has been controversial in the past. Identifying risk factors that could affect the survival of the graft and recipient is of the utmost importance.

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Canada