Myocardial Infarction (MI)
Conditions
Keywords
myocardial infarction
Brief summary
Acute myocardial infarction (AMI) remains a leading cause of mortality worldwide. Although early revascularization has markedly improved short-term outcomes, the incidence of major adverse cardiovascular events after the index event remains unacceptably high, posing a formidable clinical challenge. Contemporary risk-stratification instruments rely predominantly on a restricted set of conventional clinical variables and therefore fail to capture the full spectrum of individual pathophysiological complexity. To overcome these limitations, the present investigation aims to develop a post-AMI prognostic model that integrates comprehensive multimodal data.
Interventions
PROCEDUREPercutaneous coronary intervention
Percutaneous coronary intervention
Sponsors
Second Affiliated Hospital, School of Medicine, Zhejiang University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. Age ≥18 years old 2. Presented with myocardial infarction, including NSTEMI and STEMI 3. Undergoing successful percutaneous coronary intervention.
Exclusion criteria
1. Subjects who decline protocol-mandated follow-up or withhold informed consent. 2. Individuals whose expected survival is \< 1 year.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Recurrent myocardial infarction or cardiac death | At 24-month Follow-up | Patients received recurrent myocardial infarction or cardiac death |
| Diagnostic performance | At 24-month follow-up | Diagnostic performance of the AI-driven multimodal predictive model: area under the receiver-operating characteristic curve (AUC), sensitivity, specificity, overall accuracy, positive predictive value (PPV), and negative predictive value (NPV). |
| MACE at 24 months | At 24-month follow-up | Major adverse cardiovascular events, defined as a compisite of cardiac death, myocardial infarction, target vessel revascularization. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| MACE at 60 months | At 60-month follow-up | Major adverse cardiovascular events, defined as a compisite of cardiac death, myocardial infarction, target vessel revascularization. |
Other
| Measure | Time frame | Description |
|---|---|---|
| MACE according to pre-specified subgroups | At 24- and 60-month follow-up | MACE stratified by sex, diabetes status, and chronic kidney disease (CKD) status. |
| MACE according to physiological status | At 24- and 60-month follow-up | MACE prediction integrating physiological metrics-angiographic FFR, IMR, MRR, and CFR-of the culprit and non-culprit coronary arteries. |
Countries
China
Contacts
Primary ContactJun Jiang, MD
Outcome results
None listed