Research on Using Small-for-size Grafts for Auxiliary Liver Transplantation in the Treatment of Portal Hypertension

Innovative Technology Research on Using Small-for-size Grafts for Auxiliary Liver Transplantation in the Treatment of Portal Hypertension

Status

Enrolling by invitation

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT07247877

Enrollment

396

Registered

2025-11-25

Start date

2014-01-01

Completion date

2029-12-31

Last updated

2026-05-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Liver Transplantation

Brief summary

The objective of this observational study is to compare the safety profile of auxiliary liver transplantation using small-for-size grafts with that of conventional liver transplantation and to evaluate the efficacy of this technique. The primary research question it seeks to investigate is: "What are the differences in safety and efficacy between auxiliary liver transplantation utilizing small-for-size grafts and conventional liver transplantation for the treatment of portal hypertension?"

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

OTHER

Eligibility

Sex/Gender

ALL

Age

14 Years to No maximum

Healthy volunteers

Inclusion criteria

1. Age \> 14 years. 2. Presence of decompensated portal hypertension. 3. Meeting the indications for liver transplantation surgery. 4. International Normalized Ratio (INR) \< 2.4. 5. Scheduled to undergo orthotopic auxiliary partial liver transplantation or conventional liver transplantation.

Exclusion criteria

1. Rare liver-related anatomical variations. 2. Presence of contraindications to liver transplantation combined with malignant tumors. 3. Grade III or higher portal vein thrombosis. 4. Severe systemic diseases unrelated to the etiology or complications of portal hypertension. 5. Special surgical procedures such as dual-graft liver transplantation. 6. Special graft sources including domino liver transplantation. 7. Liver re-transplantation.

Design outcomes

Primary

Measure	Time frame
overall survival	Within one year after liver transplantation
Complications	Within one year after liver transplantation
portal hypertension resolution	Within one year after liver transplantation

Outcome results