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Flexible vs Semi-rigid URS

Semi-rigid Ureteroscopy Versus Flexible Ureteroscopy in Upper Third Ureteric Stones Management: a Prospective Randomized Trial

Status
Recruiting
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT07247617
Enrollment
100
Registered
2025-11-25
Start date
2025-10-01
Completion date
2027-01-01
Last updated
2025-11-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Ureteric Stone, Flexible Ureteroscopy, Upper Urinary Tract Stones

Brief summary

To compare the efficacy, safety, success rate, operative time, and cost-effectiveness of flexible ureteroscopy versus semirigid ureteroscopy in the management of upper ureteric stones smaller than 2 cm. The investigators' main concern in this study is Upper third ureteric stones to determine which cases can be treated with Semi-Rigid Ureteroscopy, and which one needs flexible ureteroscopy. This depends on several factors: 1. Division of the upper third of the ureter 2. Stone size 3. Stone impaction 4. Surgeon experience 5. Anesthesia 6. Ureteric dilatation above the stone 7. Mini endoscopy

Detailed description

Ureteroscopy (URS) is a widely accepted minimally invasive approach for treating ureteric stones, particularly proximal (upper) ureteral stones. Options include rigid, semirigid (often grouped as one), and flexible ureteroscopes. Flexible ureteroscopy allows deflection and access to the proximal ureter and intrarenal collecting system, facilitating treatment of stones that are difficult to reach with rigid ureteroscopes due to anatomical constraints or stone migration. Semirigid ureteroscopy has shown good efficacy, particularly for stones amenable to direct access without complex deflection, offering shorter operative times and lower costs. Studies report stone-free rates of approximately 90-93% for flexible URS and 81-90% for semirigid URS, with flexible URS having somewhat higher success in accessing stones and managing fragment migration. However, flexible URS typically incurs higher costs and longer operative times. Semirigid ureteroscopy is often the initial approach for upper ureteric stones where anatomy, stone size (\<2 cm), and location allow straightforward access. * Flexible ureteroscopy is preferred when stones are located higher in the ureter, difficult to reach by semirigid scopes, or if stone migration into the kidney occurs. It is also favored when more maneuverability is required to treat complex anatomy or large stones. * Both modalities use holmium laser lithotripsy for stone fragmentation. * Treatment choice also depends on surgeon preference, availability of equipment, and cost considerations. Despite advances, there is ongoing debate about the optimal first-line ureteroscopic approach for upper ureteric stones, balancing efficacy, safety, cost, and procedure time. Comparing flexible and rigid/semirigid ureteroscopy outcomes informs treatment algorithms, improving patient care and resource utilization, especially in differing healthcare settings.

Interventions

PROCEDUREFlexible URS

Flexible URS

PROCEDURESemi-Rigid URS

Semi-Rigid URS

Sponsors

Assiut University
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

* Patients ≥18 years * upper ureteric stone * ≤20 mm

Exclusion criteria

* Associated renal stones * Any contraindications to Anesthesia

Design outcomes

Primary

MeasureTime frame
- Stone-free rate at 3 months duration3 months

Countries

Egypt

Contacts

Primary ContactOmar Ahmed Hamada Ali
omarahmedhamada74@gmail.com+201092868286
Backup ContactMohamed Ragab Abdallah, Doctor
mohammedurology1290@gmail.com+201066237580

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026