Peri-implant Tissue Healing Assessed by Proteomic Analysis
Conditions
Keywords
peri-implant healing, proteomics, tissue regeneration, Evaluation of proteomic outcomes in peri-implant tissue healing., Pink anodized implant abutment, Grey machined implant abutment
Brief summary
The main objective of the study is to perform proteomic adsorption analysis on machined (grey) and anodised (pink) surfaces and compared them. The aim is to evaluate the regenerative potential involving improvement in the healing of peri-implant soft tissues in patients with dental implants. This surgery is indicated in healthy patients when they lost their teeth. The main question it seeks to answer is: \- In dental abutments, is anodised surface more effective than machined surface in terms of the degree of healing? The study will include patients who need this type of surgery and meet specific clinical criteria. Each patient will have one of the two dental abutments applied as part of the standard surgical procedure. Subsequently, participants will undergo clinical and proteomic follow-up assessments to evaluate the progress and extent of peri-implant tissue healing over a three-months period.
Interventions
DEVICEPink anodized implant abutment.
Participants will receive a pink anodized titanium implant abutment placed during the surgical and osseointegrated phase of treatment. Peri-implant tissue healing will be assessed over a three-month follow-up period through clinical examination and proteomic analysis.
DEVICEGrey machined implant abutment.
Participants will receive a grey machined titanium implant abutment placed during the surgical and osseointegrated phase of treatment. Peri-implant tissue healing will be assessed over a three-month follow-up period through clinical examination and proteomic analysis.
Sponsors
University of Valencia
University of Santiago de Compostela
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Number of missing teeth and, therefore, number of implants required. * A minimum of 4 implants, either single or bridges, must always be used in order to place 2 machined abutments and 2 anodised abutments. * Sufficient bone dimensions for a minimum implant diameter of 3.5-4 mm and length of 6-8 mm, without prior bone regeneration. * Patients who require indirect breast lift simultaneously with implant placement may be included in the study. * Minimum keratinised mucosa dimension of 1.5-2.0 mm in all directions. * Previous healthy bone condition for 3 months without infection. * Periodontal health with no history of periodontitis (Silness and Löe plaque index, bleeding on probing (BOP) \< 3 mm).
Exclusion criteria
* Patients unable to complete follow- up. * Implant failures. * Contamination of the sample during transfer from the abutment to the test tube.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Proteomic analysis of peri-implant tissue healing. | 7 days and 3 months after abutment placement. | Proteomic profiling of peri-implant tissues will be performed to characterise protein expression patterns associated with tissue healing, enabling the identification of molecular markers of tissue regeneration. |
Countries
Spain
Outcome results
None listed