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Impact of Prepartum Intravenous Fluid Intake on Newborn Weight Loss in the First Days of Life

Impact of Prepartum Intravenous Fluid Intake on Newborn Weight Loss in the First Days of Life

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT07243054
Acronym
PERLE
Enrollment
200
Registered
2025-11-21
Start date
2025-03-01
Completion date
2025-11-30
Last updated
2025-11-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Jaundice, Newborn, Respiratory Distress, Vascular Filling, Weight Loss

Keywords

vascular filling, newborn, weight loss, jaundice, respiratory distress

Brief summary

At birth, the infant's weight was measured daily to assess the adequacy of nutritional intake. This indicator can be influenced by various factors related to the mother, her pregnancy, as well as medical interventions during the pre-delivery phase, such as pre-partum maternal fluid intakes, and the subsequent feeding method chosen for the newborn infant. This study aimed at exploring the association between maternal vascular fluid loading during labor in the pre-partum period and neonatal weight loss in the first two days of life. The study focuses on infants fedded with infant formula. This observational, retrospective, single-center study was carried out at the Amiens University Hospital Center. The participants were mothers aged 18 and older, hospitalized in the maternity ward following full-term delivery (\> 37 weeks of gestation). Data were collected through the medical records of the patient and their newborn. The investigators hypothesize that a relationship may exist between maternal pre-partum vascular fluid loading and neonatal weight loss in the first two days of life, in infants fed with infant formula. These results could raise awareness and help adapt medical and parental approaches to neonatal weight loss.

Interventions

None listed

Sponsors

Centre Hospitalier Universitaire, Amiens
Lead SponsorOTHER

Study design

Observational model
CASE_ONLY
Time perspective
RETROSPECTIVE

Eligibility

Sex/Gender
FEMALE
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

* Full-term delivery (≥37+0 SA) * Singleton pregnancy * Mother over 18 years of age * Infant formula feeding exclusively in the maternity ward for the first 2 days

Exclusion criteria

* Mother under guardianship * Mother who does not understand French * Mother objecting to her personal data being reused for research purposes * Incomplete or incorrectly completed patient medical record * Mixed or exclusive breastfeeding * Mother presenting a hemodynamic disorder in the 12 hours preceding delivery, requiring a filling specifically for this reason * Child with renal pathology or uropathy * Children with cleft lip, palate or labio-palate

Design outcomes

Primary

MeasureTime frame
Correlation between maternal vascular fluid loading and newborn infant weight loss2 days

Secondary

MeasureTime frame
Correlation between maternal vascular fluid loading and respiratory distress2 days
Correlation between maternal vascular fluid loading and jaundice of the newborn2 days

Countries

France

Contacts

Primary ContactPierre Tourneux, Pr
Tourneux.Pierre@chu-amiens.fr33+3 22 08 76 04

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026