Use of Lactate-to-Albumin, CRP-to-Albumin, and Procalcitonin-to-Albumin Ratios to Predict Mortality in ICU Patients

Lactate-to-albumin, CRP-to-albumin and Procalcitonin-to-albumin Ratios Predict Mortality in Critically Ill Adults: a Retrospective ICU Cohort Study

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT07242027

Acronym

LAR-CAR-PAR

Enrollment

212

Registered

2025-11-21

Start date

2025-03-21

Completion date

2025-09-20

Last updated

2025-11-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cardiac Arrest, Circulatory Failure, Critical Illness, Respiratory Failure, Sepsis, Sudden Cardiac Arrest

Keywords

LAR, CAR, PAR, ICU, mortality, prediction

Brief summary

This observational study aims to determine whether three blood test ratios - lactate-to-albumin, CRP-to-albumin, and procalcitonin-to-albumin - can predict in-hospital mortality among critically ill adults. The study includes all adult patients admitted in 2024 to the ICU Ward B at the Silesian Center for Heart Diseases (SCCS) in Zabrze. Researchers will analyze retrospective clinical and laboratory data from electronic medical records, including lab values collected at ICU admission, patient demographics, diagnoses, and outcomes. The biomarker ratios will be manually calculated in Excel and statistically evaluated. The main goal is to assess whether these ratios are associated with patient survival and to identify predictive cut-off values to support early risk stratification in the ICU setting.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Age ≥ 18 years * Admission to ICU in 2024 * Availability of data for lactate, CRP, procalcitonin, and albumin

Exclusion criteria

* Missing outcome data (e.g. unknown survival status) * Lack of laboratory parameters necessary for ratio calculation

Design outcomes

Primary

Measure	Time frame	Description
In-hospital mortality	100 days from the date of ICU admission	All-cause in-hospital mortality among ICU patients during the index hospitalization.

Countries

Poland

Outcome results