Uterine Cervical Neoplasms
Conditions
Keywords
Cervical Large Cell Neuroendocrine Carcinoma, Prognosis, High-Risk Factors, Treatment Options
Brief summary
Cervical large cell neuroendocrine carcinoma (LCNEC) exhibits highly aggressive biological behavior, including strong invasiveness, a high propensity for metastasis, drug resistance, and poor prognosis, necessitating heightened clinical and pathological awareness. This study aims to summarize the clinical characteristics of LCNEC and analyze various prognostic factors to enhance understanding and vigilance toward this disease. Combined with precise pathological diagnosis, improving diagnostic accuracy is crucial for formulating treatment strategies and assessing patient prognosis.
Detailed description
This study will collect the complete medical records of patients with cervical large cell neuroendocrine carcinoma registered in the participating tertiary hospitals, and will prospectively collect the medical records of patients diagnosed with cervical large cell carcinoma. The data to be collected includes: * Patient demographics (age, place of origin, occupation, etc.) * Medical history and test results prior to initial treatment: * Present illness history * Tumor marker levels * Pelvic ultrasound * Whole abdomen CT/MRI * PET-CT * Surgical treatment details (date of surgery, surgical approach) * Pathological examination results * Administration of neoadjuvant chemotherapy and/or radiotherapy * Detailed records of all treatment courses and their efficacy (including chemotherapeutic agents, radiotherapy doses, number of cycles, etc.) * Results from follow-up examinations and imaging studies * Recurrence status and, if applicable, time to recurrence * Survival status and, if applicable, date of death For the retrospective cohort, follow-up will be completed within one month after enrollment to document current survival status and recurrence. For the prospective cohort, annual follow-ups will be conducted to record current survival status and recurrence.
Interventions
OTHERPostoperative pathological examination confirmed cervical large cell neuroendocrine carcinoma.
Postoperative pathological examination confirmed cervical large cell neuroendocrine carcinoma.
Sponsors
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Cancer Research Institute of Zhongshan City
The First Affiliated Hospital of Zhengzhou University
Qilu Hospital of Shandong University
Fujian Province Tumor Hospital
Fujian Maternity and Child Health Hospital
Zhejiang Cancer Hospital
The Third Affiliated Hospital of Kunming Medical College.
Obstetrics & Gynecology Hospital of Fudan University
Women's Hospital School Of Medicine Zhejiang University
National Cancer Center/National Cancer Clinical Medical Research Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
Peking Union Medical College Hospital
The Affiliated Tumor Hospital of Xinjiang Medical University
The First Affiliated Hospital of Anhui Medical University
Tianjin Medical University Cancer Institute and Hospital
Renmin Hospital of Wuhan University
Lili
Study design
Observational model
COHORT
Time perspective
OTHER
Eligibility
Sex/Gender
FEMALE
Healthy volunteers
No
Inclusion criteria
The diagnosis of cervical large cell neuroendocrine carcinoma (LCNEC) was confirmed by histopathological examination, meeting both clinical and histological criteria. The tumor exhibited characteristic features, including large cells with abundant cytoplasm, vesicular nuclei with prominent nucleoli, and a high mitotic rate (\>10 mitoses/10 HPFs). The growth patterns were predominantly insular, trabecular, or solid, often accompanied by peripheral palisading or rosette formation, along with focal tumor necrosis. \-
Exclusion criteria
Mixed cervical LCNEC histology, cases with missing follow-up, or patients lost to contact. \-
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Overall Survival | One month post-enrollment completion and then annual follow-up |
| Disease Recurrence | One month post-enrollment completion and then annual follow-up |
Contacts
Primary ContactLin Shitong Doctor
Outcome results
None listed