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Efficacy of Different Types of Chemical Peels in the Treatment of Acne Vulgaris

Assessment of the Efficacy and Safety of 50% Glycolic Acid, 30% Salicylic Acid, and Modified Jessner's Chemical Peels in the Treatment of Active Acne and Post-acne Hyperpigmentation: Randomized Controlled Trial

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT07240051
Acronym
AV
Enrollment
90
Registered
2025-11-20
Start date
2024-03-09
Completion date
2024-07-12
Last updated
2025-11-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acne, Peeling

Keywords

acne vulgaris, chemical peeling

Brief summary

Assessment of the Efficacy and Safety of 50% Glycolic Acid, 30% Salicylic Acid, and Modified Jessner's Chemical Peels in the Treatment of Active Acne and Post-acne Hyperpigmentation: Randomized Controlled Trial.

Interventions

Using a cotton tip applicator, a single coat of commercially prepared 50% GA peeling agent was evenly applied to the patient's face. Neutralization of the peel was done on reaching uniform erythema (endpoint) within 3-5 minutes. If frosting was observed in any area before the set time or endpoint, the area was neutralized with sodium bicarbonate

Using a cotton tip applicator, a single coat of commercially prepared 30% SA peeling agent was evenly applied to the patient's face, moving from the forehead and advancing to the cheeks, chin, glabella, nose, and perioral area. Once white crystallization appeared, patients were asked to wash their faces with water.

PROCEDUREmodified jessener

Commercially prepared MJ peel was applied using a gauze piece and light hand pressure. A single coat of peel was uniformly applied over the entire face. The coat was allowed to dry completely until erythema or frosting occurred, at which point patients were asked to wash their faces with cold water.

Sponsors

Nahla Maher Mahmoud Mahran
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender
ALL
Age
No minimum to 65 Years
Healthy volunteers
Yes

Inclusion criteria

* Facial active acne (mild and moderate cases) * post-acne hyperpigmentation * a minimum age of 18 years * skin phototype III or IV

Exclusion criteria

* Pregnant or nursing women * active infection in the treatment area (e.g., verrucae and herpes simplex) * systemic disease (hypertension, diabetes, or bleeding tendency) * systemic retinoid or laser treatment within the last 6 months * history of keloidal tendency or Aspirin sensitivity.

Design outcomes

Primary

MeasureTime frame
improvement in acne vulgaris by assessing Global acne scoring system and post-acne hyperpigmentation index6 months

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026