FindTrial
Sign In

Comparing Spinal Anesthesia With 1% Chloroprocaine Versus 1% Mepivacaine in Patients Undergoing Outpatient Primary Total Knee Arthroplasty

Randomized Controlled Trial Comparing Spinal Anesthesia With 1% Chloroprocaine Versus 1% Mepivacaine in Patients Undergoing Outpatient Primary Total Knee Arthroplasty

Status
Not yet recruiting
Phases
Phase 4
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT07239999
Enrollment
170
Registered
2025-11-20
Start date
2026-03-31
Completion date
2027-06-15
Last updated
2026-02-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anesthesia, Recovery Period

Keywords

Spinal anesthesia, Outpatient total knee arthroplasty, Mepivacaine, Chloroprocaine

Brief summary

This study or clinical trial looking to compare 2 types of freezing medications injected into the spinal fluid at the lower back between the vertebrae in patients going to have total knee replacement surgery to check for early legs movement, early discharge from recovery room, walking and hospital discharge. This could save hospital cost of such procedures.

Interventions

DRUGMepivacaine Injection

Comparing time to motor block recovery in PACU, time to PACU discharge, time to ambulation and length of hospital stay

DRUGChloroprocaine Injection

Comparing time to motor block recovery in PACU, time to PACU discharge, time to ambulation and length of hospital stay

Sponsors

Nova Scotia Health Authority
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
SINGLE (Caregiver)

Masking description

Surgeons, PACU Nurses, OR Nurses, Physical therapists

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

* ASA I-III * Elective outpatient TKA * BMI less than 40 * Ability to provide surgical consent

Exclusion criteria

* Patient refusal * Opioid tolerant * Any contraindications to spinal anesthesia * Chronic opioid use 3months or more

Design outcomes

Primary

MeasureTime frameDescription
Time to complete recovery of motor blockTime from the intrathecal drug injection to the first documented instance of complete motor block recovery Bromage 0. Within approximately 2 hours for the Chloroprocaine group and 4 hours for the Mepivacaine group.—
Time to complete motor block recovery of lower limbs after spinal anesthesiaFrom the time of intrathecal drug injection to PACU discharge. Within approximately 3 hours for the Chloroprocaine group and 5 hours for the Mepivacaine group.Motor block will be assessed by PACU nurses in PACU using standard Bromage motor scale.

Contacts

CONTACTHUSAM M NASHNOUSH, MBBCH, FRCPC
husam.nashnoush@nshealth.ca001-902-410-9062
CONTACTMohamed H Nashnoush, MED2
mnashnoush@dal.ca001-902-266-6010
PRINCIPAL_INVESTIGATORHUSAM M NASHNOUSH, MBBCH, FRCPC

Dalhousie University

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 7, 2026