DEXDES Trial: Dexmedetomidine-Desflurane Combination in Laparoscopic Colectomy

Efficacy and Safety of Dexmedetomidine Combined With Desflurane in Laparoscopic Colectomy: A Randomized Double-Blind Controlled Clinical Trial (DEXDES Trial)

Status

Recruiting

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT07239479

Enrollment

Registered

2025-11-20

Start date

2025-12-01

Completion date

2027-01-30

Last updated

2025-12-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Colorectal Neoplasms

Keywords

Dexmedetomidine, Desflurane, General anesthesia, Colorectal surgery, ERAS, Hemodynamic stability

Brief summary

This randomized double-blind controlled clinical trial aims to evaluate the efficacy and safety of combining Dexmedetomidine with Desflurane in patients undergoing elective laparoscopic colectomy. The study will assess whether the combination can reduce Desflurane consumption, improve intraoperative hemodynamic stability, and enhance postoperative recovery compared to Desflurane alone.

Detailed description

Dexmedetomidine, a selective alpha-2 adrenergic agonist, has sedative and analgesic properties without significant respiratory depression. Desflurane, a volatile anesthetic with low blood-gas solubility, allows rapid induction and emergence. Combining these two agents may provide anesthetic-sparing effects and promote faster postoperative recovery under ERAS protocols. This study will enroll 40 adult patients undergoing elective laparoscopic colectomy at Tam Anh General Hospital, Vietnam. Participants will be randomized into two groups: Dexmedetomidine + Desflurane versus Desflurane alone. The primary outcome is average Desflurane consumption per hour, with secondary outcomes including hemodynamic parameters, Fentanyl use, emergence quality, and incidence of postoperative nausea and vomiting.

Interventions

DRUGDexmedetomidine + Desflurane

Dexmedetomidine bolus 1 µg/kg IV over 15 minutes before induction, followed by continuous infusion 0.5 µg/kg/h during surgery. Desflurane administered at 1 MAC with EtControl mode.

DRUGDesflurane + Normal Saline

Normal saline infusion with identical timing and volume as the intervention group. Desflurane administered at 1 MAC with EtControl mode.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender

ALL

Age

18 Years to 65 Years

Healthy volunteers

Inclusion criteria

* Age 18-65 years * ASA Physical Status I-II * Elective laparoscopic colectomy * Written informed consent provided

Exclusion criteria

* Severe cardiac, hepatic, or renal disease * COPD or bronchial asthma * Chronic opioid or psychotropic medication use * Atrioventricular block (grade II-III), sick sinus syndrome * Significant intraoperative bleeding or hemodynamic instability

Design outcomes

Primary

Measure	Time frame	Description
Average Desflurane consumption per hour (mL/h) during surgery.	During surgery	Average Desflurane consumption per hour (mL/h) during surgery.

Countries

Vietnam

Contacts

Primary ContactPhan Quoc Thai, MD

thaipq@tahospital.vn+84 964 152 360

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026