Alzheimer Disease (AD), Dementia Alzheimer Type, Air Pollution Exposure
Conditions
Keywords
cognitive function, Alzheimer Disease, Diesel Exhaust, Olfactory nerve
Brief summary
The goal of this study is to study the effect exposure to air pollution and its effect on development of dementia. Does the diesel exhaust change the function of the olfactory system? Have the exposures measurable effects on the sense of smell and cognitive ability? Forty people are exposed to diesel exhaust exhaust and filtered air. The exposures are blinded and in a randomized order. Both groups undergo biopsies of the olfactory epithelium in the nose under local anesthesia after the exposures and after performing cognitive test.
Interventions
During exposure to diesel exhaust, participants alternate between 15-minute periods of rest and exercise on an ergometer cycle with a workload that results in a minute ventilation of 20L/min/m² body surface area. Symptom recording is done every 30 minutes, following a routine based on a modified Borg scale.
OTHERFiltered air
During exposure to filtered air, participants alternate between 15-minute periods of rest and exercise on an ergometer cycle with a workload that results in a minute ventilation of 20L/min/m² body surface area. Symptom recording is done every 30 minutes, following a routine based on a modified Borg scale
Sponsors
University Hospital, Umeå
University of Eastern Finland
Czech Academy of Sciences
Umeå University
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
DIAGNOSTIC
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
20 Years to 70 Years
Healthy volunteers
Yes
Inclusion criteria
* Healthy * non-smoker
Exclusion criteria
* Allergic rhinitis * Asthma * Diabetes mellitus * Kidney or liver failure * Angina pectoris or previous ventricular arrhythmia * Systolic blood pressure \>190 mmHg or \<100 mmHg * Previous blood disease * Blood donation in the last three months prior to study start * Previous or ongoing tobacco smoking and exposure to air pollution in the workplace * Absence of informed consent
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Diesel exhaust causes cellular dysfunction of the olfactory system | 3 years. | RNA sequencing and DNA methylation will be conducted to identify biomarkers for acute exposure to diesel exhaust. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Cognitive test | 3 years | Olfactory function well be evaluated by using sniffin' sticks, and a Letter-Digit Substitution Test as a marker for cognitive processing speed. |
Countries
Sweden
Outcome results
None listed